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| 新老工艺红茴香注射液抗炎镇痛作用的比较 | |
| 作者姓名： | 赵氚 张沂 季辉 段蕴攸 贾静 丁丽菊 |
| 作者单位： | 1海军总医院药剂科，北京 100048;2中国药科大学药学院， 江苏 南京 210038 |
| 摘 要： | 目的:;比较新工艺与老工艺生产的红茴香注射液的抗炎镇痛作用。方法:;通过大鼠炎性足趾肿胀试验和二甲苯致小鼠耳肿胀试验比较新老工艺红茴香注射液的抗炎作用，通过醋酸致小鼠的扭体试验比较新老工艺红茴香注射液的镇痛作用。结果:;新工艺和老工艺的7.5mL/kg和15mL/kg剂量组在给药后4h内（包括4h）能显著减轻角叉菜胶引起的大鼠足肿胀，与阴性对照组相比有显著差异（P<0.05）。红茴香注射液老工艺30mL/kg、15mL/kg和新工艺30mL/kg、15mL/kg、7.5mL/kg剂量组能显著抑制二甲苯引起的小鼠耳肿胀；与老工艺相比，新工艺效果较好且有显著性意义(P<0.05)；醋酸扭体试验结果显示，红茴香注射液新工艺中剂量组能显著提高小鼠的痛阈值，与老工艺相比，差异有显著性意义(P<0.05)。结论:;新工艺生产的红茴香注射液抗炎镇痛作用优于老工艺。 |
| 关 键 词： | 红茴香 抗炎 镇痛 |
| 收稿时间： | 2010/11/28 0:00:00 |
| 修稿时间： | 2011/3/21 0:00:00 |
Anti-inflammatory and Analgesic Effects of Hong huixiang Injection by the old and new craft |
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| Authors: | ZHAO Chuan ZHANG Yi JI Hui DUAN Yun-you JIA Jing DING Li-ju |
| Institution: | ZHAO Chuan1,ZHANG Yi1,JI Hui2,DUAN Yun-you1,JIA Jing2,DING Li-ju2(1.Medicament branch,Navy General Hospital,Beijing,100048,China,2.School of Pharmacy,China Pharmaceutical University,Nanjing,210009,China) |
| Abstract: | OBJECTIVE The aim of our study is to compare the anti-inflammatory and analgesic effects of Hong huixiang Injection by the old and new craft.METHODS Rat paw oedema and mice ear edema test,were used to evaluate the anti-inflammatory activity between the two injections.Acetic acid-induced writhing test was used to determine analgesic effects between the two injections.RESULTS Both of the injections displayed marked anti-inflammatory and analgesic effects.CONCLUSION The anti-inflammatory and analgesic effects ... |
| Keywords: | Honghuixiang Anti-inflammatory activity Analgesic effects |
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