| 白藜芦醇对非酒精性脂肪肝大鼠的作用机制研究 |
| |
| 引用本文： | 黄英,李雪兰,蒋凤荣. 白藜芦醇对非酒精性脂肪肝大鼠的作用机制研究[J]. 南京中医药大学学报, 2011, 27(4): 366-368 |
| |
| 作者姓名： | 黄英 李雪兰 蒋凤荣 |
| |
| 作者单位： | 1.湖南常德职业技术学院，湖南 常德:;415000 |
| |
| 基金项目： | 湖南省常德市科技局资助项目 |
| |
| 摘 要： | 目的:;探讨白藜芦醇对非酒精性脂肪肝大鼠的分子机制。方法:;实验分组:正常对照组；模型组；白藜芦醇低剂量组；白藜芦醇高剂量组。正常SD大鼠高脂饲养8周，复制大鼠非酒精性脂肪肝模型，组织病理学观察，Realtime PCR检测氧化及凋亡相关基因，血清生化检测。结果:; 白藜芦醇治疗组和模型组比较，形态学显示治疗组肝肌细胞变性坏死明显减轻；氧化应激相关指标SOD1活性增高；均有显著性差异(P<0.05)。 结论:;白藜芦醇调控氧化应激相关基因表达，减轻肝细胞的脂质过氧化损伤，改善肝脏功能。
|
| 关 键 词： | 白藜芦醇 非酒精性脂肪肝模型 氧化应激 |
| 收稿时间： | 2011-04-18 |
| 修稿时间： | 2011-05-11 |
Study on the Mechanism of Resveratrol on Rats with Non-Alcoholic Fatty Liver |
| |
| HUANG Ying,LI Xue-lan,JIANG Feng-rong. Study on the Mechanism of Resveratrol on Rats with Non-Alcoholic Fatty Liver[J]. Journal of Nanjing University of Traditional Chinese Medicine(Natural Science), 2011, 27(4): 366-368 |
| |
| Authors: | HUANG Ying LI Xue-lan JIANG Feng-rong |
| |
| Affiliation: | HUANG Ying1,LI Xue-lan1,JIANG Feng-rong2*(1.Changde Vocational Technical College in Hunan Province,Changde,415000,China,2.College of Basic Medicine,Nanjing University of Chinese Medicine,Nanjing,210046,China) |
| |
| Abstract: | OBJECTIVE To investigate the molecular mechanism of resveratrol's effect on rats with non-alcoholic fatty liver.METHODS We established normal control group,model group,low dosage resveratrol group,and high dosage resveratrol group.The model of non-alcoholic fatty liver from normal SD rats was duplicated after high fat diet was administrated for 8 weeks.Histopathologic observation,biochemical test for serum,and real time PCR for detecting the related genes of oxidation and apoptosis were carried out.RESULTS ... |
| |
| Keywords: | resveratrol non-alcoholic fatty liver model oxidative stress |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《南京中医药大学学报》浏览原始摘要信息 |
|
点击此处可从《南京中医药大学学报》下载全文 |
|
