Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin,China |
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| Authors: | Xiao-yan Li Jin-ying Chen Mei Kong Xu Su Yan-ping Yi Ming Zou and Hua Zhang |
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| Institution: | (1) School of Basic Medical Sciences, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, 300070 Tianjin, People’s Republic of China;(2) Tianjin Centers for Disease Control and Prevention, No. 76 Hualong Road, Hedong District, 300011 Tianjin, People’s Republic of China;(3) Tianjin Children’s Hospital, Tianjin, People’s Republic of China; |
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| Abstract: | Human metapneumovirus (hMPV) has recently been recognized as an important respiratory pathogen, especially in children. At
present, our understanding of the characteristics of hMPV from China is very limited. Nasopharyngeal aspirates were taken
from 310 hospitalized pediatric patients. Twenty (6.5%) of them were infected with hMPV, and they all developed pneumonia.
Sixty five percent (13/20) of the cases were under 12 months. Phylogenetic analysis of F gene fragments indicated that three
sub-genotypes of hMPV(A2a/A2b, B1,B2) circulated in Tianjin and A2b was the predominant subtype. The Vero-E6 cell line was
better than LLC-MK2 for hMPV isolation. Three hMPV strains were successfully isolated using the Vero-E6 cell line. |
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