| 安胃汤对CAG模型大鼠胃黏膜病理改变及TFF1mRNA表达的影响 |
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| 引用本文： | 唐友明,林寿宁,韦维,朱永苹,刘伟锋,万小刚. 安胃汤对CAG模型大鼠胃黏膜病理改变及TFF1mRNA表达的影响[J]. 南京中医药大学学报, 2011, 27(4) |
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| 作者姓名： | 唐友明 林寿宁 韦维 朱永苹 刘伟锋 万小刚 |
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| 作者单位： | 广西中医学院附属瑞康医院,广西,南宁,530011 |
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| 基金项目： | 广西自然科学基金，国家中医药管理局中医药行业科研专项项目，广西教育厅科研基金资助课题 |
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| 摘 要： | 目的 探讨安胃汤对实验性慢性萎缩性胃炎大鼠模型的TFF1mRNA表达的影响.方法 采用甲基硝基亚硝基胍(MNNG)慢性萎缩性胃炎大鼠模型,48只清洁级健康雄性Wistar大鼠随机分为空白组、病理模型组、安胃汤组、胃复春对照组共4组.光学显微镜观察胃黏膜病理变化,实时定量PCR方法 观察安胃汤对实验性慢性萎缩性胃炎大鼠模型胃黏膜TFF1mRNA表达的影响.结果 安胃汤与胃复春均能改善胃黏膜的病理形态,但以安胃汤效果为佳.与病理模型组相比,安胃汤组和胃复春对照组均显著提高TFF1mRNA/β-actin相对表达量比值(0.86±0.13vs0.54 ±0.10 and 0.83±0.10vs0.54±0.10,P<0.01),安胃汤组优于胃复春对照组(0.86 ±0.13vs0.83±0.10,P<0.01).结论 安胃汤能够改善慢性萎缩性胃炎大鼠模型胃黏膜的病理形态,可能通过增加胃黏膜TFF1mRNA表达而起到治疗CAG作用.
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| 关 键 词： | 安胃汤 慢性萎缩性胃炎 实验研究 |
Anwei Decoction's Effect on Pathological Changes of Gastric Mucosa and Expression of TFF1mRNA in Rats with Chronic Atrophic Gastritis |
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| TANG You-ming,LIN Shou-ning,WEI Wei,ZHU Yong-ping,LIU Wei-feng,WAN Xiao-gang. Anwei Decoction's Effect on Pathological Changes of Gastric Mucosa and Expression of TFF1mRNA in Rats with Chronic Atrophic Gastritis[J]. Journal of Nanjing University of Traditional Chinese Medicine(Natural Science), 2011, 27(4) |
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| Authors: | TANG You-ming LIN Shou-ning WEI Wei ZHU Yong-ping LIU Wei-feng WAN Xiao-gang |
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| Affiliation: | TANG You-ming,LIN Shou-ning*,WEI Wei,ZHU Yong-ping,LIU Wei-feng,WAN Xiao-gang(Ruikang Hospital Affiliated to Guangxi College of Traditional Chinese Medicine,Nanning,530011,China) |
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| Abstract: | OBJECTIVE To explore the effect of Anwei Decoction(AD) on the expression of TFF1mRNAs in rats with chronic atrophic gastritis(CAG).METHODS Forty-eight healthy rats were randomly divided into 4 groups: normal control group,pathologic model group(group A),Anwei Decoction group(group B),and Weifuchun control group(group C).In addition to normal control group,CAG in all of them was induced by N-methy-N-Nit ro-N-Nitroguanidine(MNNG).Pathological changes of gastric mucosa were observed by optical microscope.The e... |
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| Keywords: | TFF1 |
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