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| 包裹脑源性神经营养因子壳聚糖/海藻酸钠微囊的制备及体外释药研究 | |
| 引用本文： | 吴河坪,王宁利,曾明兵,陈静嫦,范志刚.包裹脑源性神经营养因子壳聚糖/海藻酸钠微囊的制备及体外释药研究[J].广州医药,2011,42(4):56-58. |
| 作者姓名： | 吴河坪 王宁利 曾明兵 陈静嫦 范志刚 |
| 作者单位： | 1. 中山大学中山眼科中心眼肌科,广州,510060 2. 首都医科大学附属北京同仁眼科中心,北京,100730 3. 广州医学院第二附属医院眼科,广州,510260 |
| 摘 要： | 目的 研制包裹脑源性神经营养因子(brain derived neurotrophic factor,BDNF)的壳聚糖/海藻酸钠微囊,并测定其体外药物释放动力学.方法 采用改良超声雾化法,将含BDNF的壳聚糖溶液加入超声雾化仪中雾化喷入海藻酸钠溶液中制成包裹BDNF的壳聚糖/海藻酸钠微囊混悬液.采用高效液相色谱法(h... |
| 关 键 词： | 脑源性神经营养因子 壳聚糖 海藻酸钠 微囊 释药 |
Preparation and drug-release properties in vitro of chitosan/alginate microcyst encapsulating BDNF |
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| Institution: | Wu Heping,Wang Ningli,Zen Mingbing,et al.Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510060,China |
| Abstract: | Objective To construct chitosan/alginate microcyst encapsuling BDNF and measure its vitro pharmacokinetics.Methods We use ultrosound atomization method to construct chitosan/alginate microcyst encapsuling BDNF.High performance liquid chromatography(HPLC) was used to analyse its in vitro pharmacokinetics.Results Chitosan/alginate microcyst has circular transparent granule shape,with diameter rangeing from 3 to 5 micrometers.We analyse daily release dose of BDNF with SPSS statistical software.The results showed that the relation between BDNF accumulative release dose and time was linear,which was consistent with zero order processes.Conclusion The preparing technology for chitosan/alginate microcyst encapsuling BDNF used in this test is dependable,and the in vitro release of BDNF from the microcyst is sustained |
| Keywords: | Brain derived neurotrophic factor Chitosan Sodium alginate Microcyst Drug-Release |
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