| HPLC法测定小细胞肺癌病人血中的鬼臼乙义甙 |
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| 引用本文： | 何晓英 朱运奎. HPLC法测定小细胞肺癌病人血中的鬼臼乙义甙[J]. 中国医院药学杂志, 1994, 14(5): 199-201 |
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| 作者姓名： | 何晓英 朱运奎 |
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| 作者单位： | 兰州军区总医院 |
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| 摘 要： | 以甲醇：水（５５：４５）为流动相，在ＤＵＰＯＮＴＺＯＲＢＡＸ－ＯＤＳ反相柱上，以苯妥英钠为内标，建立了测定人血浆中鬼臼乙义甙的ＨＰＬＣ方法学。鬼臼乙义甙的平均回收率为８１．６８％，最低检出量为０．３μｇ／ｍｌ。方法简便，灵敏度高，专一性好。并进行了临床病人的血浓监测。方法可靠。
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| 关 键 词： | 鬼臼乙义甙，HPLC，血药浓度监测 |
Determination of the blood concentration of etoposide in small cells lung carcinoma by HPLC |
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| He Xiao-ying,Zhu Yun-kui,Zhou Yu-Xi,Xie Jing-wen,Xie Ting-quan. Determination of the blood concentration of etoposide in small cells lung carcinoma by HPLC[J]. Chinese Journal of Hospital Pharmacy, 1994, 14(5): 199-201 |
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| Authors: | He Xiao-ying Zhu Yun-kui Zhou Yu-Xi Xie Jing-wen Xie Ting-quan |
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| Abstract: | n Ep-HPLC method is described for the determination of etoposide in plasma. Plasma was extracted with cloroform,theorganic phase was separated. The procedure was simple. Etoposide was separated on a DU PONT ZORBAX-ODS columm, us-ing methanol-water(55:45 )as mobil phase. The detecion wavelength was 242nm. The limit of detection was 0.3ug/ml; theaveravge recovery was 81.7%.The method has been applied to the study on pharmacokinetics of etoposide produced in Chinain 6 small cells lung carcinoma volunteers |
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| Keywords: | HPLC Etoposide TDM |
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