T1期肺癌原发灶18F-FDG摄取与转移的关系

目的 探讨T1期肺癌原发灶18F-脱氧葡萄糖(FDG)摄取与病灶大小、淋巴结转移、远处转移、病理类型的关系.方法 对61例治疗前行全身18F-FDG PET/CT扫描的T1期肺癌患者,确定其临床分期以及原发灶大小(最大径)和18F-FDG摄取值以最大标准摄取值(SUVmax)表示],并分为无转移组、仅淋巴结转移组和有远处转移组.分析各组的18F-FDG摄取与原发灶大小、淋巴结转移、远处转移、病理类型的关系.结果 原发灶大小与SUVmax呈正相关(r=0.466,P＜0.05),各组间大小差异无统计学意义.SUVmax在无转移组(5.05±1.97)与仅淋巴结转移组(7.96±2.98)、远处转移组(8.25±2.93)之间差异均有统计学意义(P值分别为0.003,0.002).而仅淋巴结转移组与远处转移组之间SUVmax差异无统计学意义(P=0.718).肺腺癌、鳞癌的大小(t=1.566,P=0.111)和SUVmax(t:0.478,P=0.623)差异均无统计学意义.结论 T1期肺癌原发灶18F-FDG摄取可能对预测转移有一定的价值.

18F-FDG uptake of primary tumor and metastasis in T1 lung cancer patients

Objective The 18F-fluorodeoxyglucose(FDG)uptake degree in primary lung cancer has been assumed to link to tumor aggressiveness and long-term prognosis.The purpose of this study was to evaluate the value of the FDG maximum standardized uptake value(SUVmax)for TNM staging and pathological behavior in stage T1 lung cancer cases.Methods Sixty-one newly diagnosed lung cancer patients were enrolled in this study.All primary lesions were confirmed by operation or biopsy.Sixty-one cases were divided into 3 groups:13 cases in T1N0M0,25 cases in lymph node metastasis only(T1N1-3M0)and 23 cases in distant metastasis(T1N0-3M1).The relationship between SUVmax of primary lesion and its size,TNM staging,histological characteristic had been analyzed.SPSS 13.0 was used for date analysis.Results There was a positive correlation between the SUVmax and size of the primary lesion(r=0.466,P＜0.05).The SUVmax were 5.05±1.97,7.96±2.98,8.25±2.93 in T1N0M0,T1N1-3M0,T1N0-3M1 respectively.Significant statistical difference Was found between T1N0M0 and T1N1～3M0 or T1N0～3M1 group(ANOVA test,P=0.002,P=0.003,respectively).But there Was no difference between the lymph node metastasis only and distant metastasis group(ANOVA test,P=0.718).There was no differenee between squamous cell carcinoma and adenocarcinoma beth in size(t=1.566,P=0.111)and SUVmax(t=0.478,P=0.623).Conclusion SUVmax may be used as a predictor for regional and distant metastasis in stage T1 lung caner patients.