伴有生发中心增生的血管免疫母细胞性T细胞淋巴瘤的临床病理研究

目的探讨伴有生发中心增生的血管免疫母细胞性T细胞淋巴瘤的临床、病理形态学及免疫表型特点。方法对4例伴有生发中心增生的血管免疫母细胞性T细胞淋巴瘤标本进行形态学、免疫组化及EB病毒原位杂交观察,并进行临床随访。结果 4例病例均显示生发中心增生伴血管免疫母细胞性增生,但是套区变薄,境界不清。3例表达CD10,2例表达CXCL13,4例表达PD-1。4例均见EBV(+)的母细胞。4例在就诊时均处于临床进展期,3例得到随访,其中2例死亡。结论诊断伴有生发中心增生的血管免疫母细胞性T细胞淋巴瘤,必须将形态学、免疫表型特征和临床表现密切结合。

Clinicopathological study on angioimmunoblastic T-cell lymphoma with hyperplastic germinal centres

Objective To explore the clinicopathological features of angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers. Methods Four cases of angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers were studied by light microscopy,immunohistochemical method and in situ hybridization. Follow-up had been taken for 6 ～ 31 months in 3 cases. Results Follicular hyperplasia along with angioimmunoblastic proliferation had been seen in 4 cases,as well as poorly developed mantle zones with ill-defined borders. The expression of CD10 had been seen in 3 cases,and positive expression of CXCL13 was seen in 2 cases,and expression of PD-1 in 4 cases. EBV（ ＋） immunoblasts were present in 4 cases. Their clinical courses were characterized by relentless and rapid progress,and 2 patients died within31 months. Conclusion The accurate diagnosis of angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers. needs combination of histopathological examination,immunophenotype detection and study of clinical features.