Correlation between incidence of 1,2-dimethylhydrazine-induced colon carcinomas and DNA damage in six genetically different mouse strains |
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| Authors: | C Bolognesi L C Boffa |
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| Affiliation: | 1. Department of Pharmacology, Central University of Punjab, Gudda, Bathinda 151401, India;2. Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh;1. Department of Environmental Science & Engineering, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, India;2. Maharshi Dayanand University, Rohtak, Haryana, India;3. Kurukshetra University, Kurukshetra, Haryana, India;4. Shaheed Hassan Khan Mewati Medical College, Mewat, Haryana, India |
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| Abstract: | Mice from strains with different susceptibility to the colon-specific carcinogen 1,2-dimethylhydrazine (DMH) were tested for DNA damage in liver, kidney and colon after administration of the compound at a dosage that has been reported to induce a high incidence of adenocarcinoma in the colon of rodents. DNA breaks were evaluated from their elution rate constant according to the alkaline elution technique. We found that 4 h after administration of the carcinogen there was a substantial and comparable DNA damage in liver and kidney of all strains examined. Conversely, colon DNA damage was hardly above control levels in the carcinogen-resistant strains. The highest DNA damage was detected in the most susceptible strain and was slightly lower in the two other susceptible strains. We propose that the extent of DNA breakage in a target organ could be one of the factors determining organ-specific and strain-specific susceptibility to DMH. |
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