Telomerase activity in oral lichen planus |
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Authors: | Kobkan Thongprasom Apiwat Mutirangura Surasak Cheerat |
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Institution: | Oral Medicine Department, Faculty of Dentistry;Genetics Unit, Department of Anatomy, Faculty of Medicine;Oral Pathology Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand |
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Abstract: | The purpose of this study was to determine the expression of telomerase in refractory oral lichen planus. Using a polymerase chain reaction-based telomerase activity assay, we investigated telomerase activity in 20 oral lichen planus specimens (erosive 9, atrophic 11). Telomerase activity was detected in 14 cases (erosive 7, atrophic 7). Furthermore, 13 cases of lichen planus with mild dysplasia proved telomerase-positive in eight specimens and six of seven cases devoid of dysplasia were also positive in the telomerase assay. The data indicate that, in general, telomerase activity might be frequently detectable in OLP. The data also suggest that telomerase activity might not be particularly associated with the premalignant phenotype in OLP. |
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Keywords: | Key words: malignant transformation oral lichen planus telomerase |
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