| 3-羟基异黄酮对卵巢癌的防治作用 |
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| 引用本文： | 李文学.3-羟基异黄酮对卵巢癌的防治作用[J].国外医学(计划生育．生殖健康分册),2009(3):197-200. |
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| 作者姓名： | 李文学 |
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| 作者单位： | 复旦大学附属妇产科医院;威海市妇女儿童医院妇产科; |
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| 摘 要： | 3-羟基异黄酮(genistein)属于异黄酮化合物,为一弱植物雌激素,在肿瘤的发生、发展阶段存在着多重抑制效应,其抗肿瘤机制为调节雌激素受体、抑制酪氨酸蛋白激酶活性、抑制血管形成、增强抗氧化酶的活性、调节细胞周期、诱导细胞凋亡、抑制拓扑异构酶的活性等,与多种肿瘤的发生低风险有关。3-羟基异黄酮也可作为一种辅助治疗药物,提高肿瘤细胞对放疗的敏感性,增强化疗药物的抗肿瘤作用,降低肿瘤的复发及转移。综述3-羟基异黄酮抗肿瘤作用机制及其在卵巢癌中的研究。
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| 关 键 词： | 3-羟基异黄酮 卵巢肿瘤 预防 治疗 |
The Preventive and Therapeutic Effects of Genistein on Ovarian Cancer |
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| Authors: | LI Wen-xue SUN Hong |
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| Institution: | LI Wen-xue,SUN Hong. The Affiliated Obstetrical , Gynecological Hospital of Fudan University,Shanghai 200011,China |
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| Abstract: | Genistein, as a weak phytoestrogen, which belongs to isoflavone compounds, has multiple depressive effects during tumor occurrence and development. Genistein is related to the low risks of tumorigenesis with its anti-tumor mechanisms such as the modulation of estrogen receptor, inhibition of tyrosine protein kinase (PTK) activity, suppression of angiopoiesis, enhancement of antioxidant activity, regulation of cell cycle, induction of apoptosis, and inhibition of topoisomerases activity. Genistein can also b... |
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| Keywords: | Genistein Ovarian cancer Prevention Treatment |
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