冠心病患者颈动脉内膜-中层厚度及微量白蛋白尿与冠状动脉病变的关系

目的：探讨冠心病患者颈动脉内膜-中层厚度及微量蛋白尿与冠状动脉病变的关系。方法：选取我院2011年2月至2013年4月60例冠心病患者作为研究对象，根据血管病变程度分为冠状动脉造影正常组16例、单支病变组16例、双支病变组14、三支及多支病变组14例，检查患者双侧颈动脉中层厚度及斑块情况，同时测定微量白蛋白尿，分析冠心病病变程度和颈动脉硬化及微量白蛋白尿水平的相关性。结果：与冠状动脉正常组相比，冠状动脉病变组的颈动脉内膜明显增厚，而且随着病变程度的加重，其颈动脉内膜-中层厚度、斑块发生率以及微量蛋白尿明显增加，差异具有统计学意义，P＜0．05。结论：颈动脉内膜中层厚度及微量白蛋白尿水平与冠状动脉的病变程度具有相关性，且通过测定颈动脉中层厚度及微量蛋白尿含量可预测冠状动脉的病变程度。

Relationship of the Carotid Intima-media Thickness and Microalbuminuria with the Severity of Coronary Artery Lesions to the CHD

Objective： To investigate the
relationship of the carotid intima-media
thickness and mi-croalbuminuria with the severity
of coronary artery lesions to the coronary heart
disease .Method：60 patients treated with coronary
arteriography in our hospital from Feb.2011 to
Apr.2013 were selected and divided into coronary
artery imaging normal group （ n =16 ） , single-
vessel disease group （ n =16 ） , double -vessel
disease group （ n =14 ） and three-multivessel
disease group （ n =14 ） .Gensini method was used
to calcu-late the integral of coronary artery
lesion degree;bilateral carotid IMT and plaque
situation were checked up;microalbuminuria value
was measured, the relationship of the carotid IMT
and microalbuminuria with the se-verity of
coronary artery lesions were analyzed.Result：IMT
of single -vessel disease group, double -vessel
disease group and three-multivessel disease group
were all higher than those of coronary artery
imaging nor-mal group;carotid IMT, plaque
occurrence rate, plaque integral and
microalbuminuria were all found in-creased
followed the severity of the coronary artery
lesion , the differences were all statistically
significant （ all P 〈0.05）.Conclusion： Carotid
IMT and microalbuminuria can predict the severity
of coronary artery le-sions and have important
clinical significance of evaluating the coronary
heart disease .