重度脂肪肝与血脂异常的相关性研究

目的：探讨脂肪肝病情严重程度与血脂异常之间的相关性。方法：选取200例脂肪肝患者为脂肪肝组,其中轻度44例,中度102例,重度54例,选取肝脏无明显异常中老年体检者100例为对照组,检测两组血脂浓度。结果：总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）脂肪肝组分别为（5.57±1.38）、（3.13±2.18）、（0.92±0.26）、（3.71±0.93）mmol/L,对照组为（4.24±0.75）、（1.34±0.82）、（1.21±0.28）、（2.19±0.78）mmol/L,两组比较差异具有统计学意义（P〈0.05）;轻度脂肪肝患者为（4.98±0.95）、（1.43±0.99）、（1.15±0.26）、（2.43±0.80）mmol/L,中度为（5.63±1.14）、（2.32±1.81）、（1.06±0.25）、（3.15±0.91）mmol/L,重度为（6.14±1.56）、（3.48±2.35）、（0.87±0.28）、（3.82±0.94）mmol/L,不同分度脂肪肝患者之间比较差异具有统计学意义（P〈0.05）;非条件Logistic多因素回归分析结果显示TG是引起脂肪肝患病的独立危险因素（P〈0.05）,相关性分析脂肪肝病情严重程度与TC、TG、LDL-C浓度之间具有正相关（P〈0.05）,与HDL-C浓度之间具有弱负相关（P〈0.05）。结论：脂肪肝病情严重程度与血脂水平异常之间具有密切相关性。

Correlation between severe fatty liver and dyslipidemia

Objective：To investigate the correlation between severity of fatty liver disease and dyslipidemia.Methods：Selected 200patients with fatty liver as fatty liver group including 44mild cases,102 moderate cases,and 54severe cases,100cases without obvious abnormality were selected as control group.Blood lipid concentrations were detected in both groups.Results：Total cholesterol（TC）,triglycerides（TG）,high-density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C） of the fatty liver group were（5.57±1.38）mmol/L,（3.13±2.18）mmol/L,（0.92±0.26）mmol/L,（3.71± 0.93）mmol/L,respectively.And the corresponding levels in the control group were（4.24±0.75）mmol/ L,（1.34±0.82）mmol/L,（1.21±0.28）mmol/L,（2.19±0.78）mmol/L,showing significant differences between the two groups（Pall0.05）.The above mentioned levels in the mild cases,moderate cases and severe cases were（4.98±0.95）mmol/L,（1.43±0.99）mmol/L,（1.15±0.26）mmol/L,（2.43±0.80） mmol/L,vs.（5.63±1.14）mmol/L,（2.32±1.81）mmol/L,（1.06±0.25）mmol/L,（3.15±0.91）mmol/L, vs.（6.14±1.56）mmol/L,（3.48±2.35）mmol/L,（0.87±0.28）mmol/L,（3.82±0.94）mmol/L,showing significant differences among patients with different severity（P0.05）.Unconditioned Logistic multifactor regression analysis results showed that the TG is independent risk factors of fatty liver disease（P0. 05）,the correlation analysis showed severity of fatty liver disease were positively correlated with TC,TG, LDL-C levels.（P0.05）,and a weak negative correlation between HDL-C concentration and the disease severity was aloes observed（P0.05）.Conclusion：Fatty liver disease is closely correlated with severity and abnormal blood lipid levels.