淫羊藿苷对维甲酸致大鼠骨质疏松影响的研究 |
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引用本文: | 朱贵忱,刘明雨,孙利锋,才智,宋雪花.淫羊藿苷对维甲酸致大鼠骨质疏松影响的研究[J].河北医药,2014,0(1):8-10. |
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作者姓名: | 朱贵忱 刘明雨 孙利锋 才智 宋雪花 |
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作者单位: | 朱贵忱 (066000,河北省秦皇岛市海港医院骨科); 刘明雨 (066000,河北省秦皇岛市海港医院骨科); 孙利锋 (066000,河北省秦皇岛市海港医院骨科); 才智 (066000,河北省秦皇岛市海港医院骨科); 宋雪花 (河北省青龙满族自治县县医院妇产科); |
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基金项目: | 河北省中医药管理局科研计划项目(项目编号:编号2012187) |
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摘 要: | 目的观察淫羊藿苷对维甲酸致大鼠骨质疏松的影响。方法大鼠分为对照组、模型组、淫羊藿苷低、中、高剂量组,每组10只。70ms/kg维甲酸灌胃2周制备大鼠骨质疏松模型。淫羊藿苷组灌胃给予50、100、200mg/kg淫羊藿苷,连续4周。测定血和骨中相关指标;测定骨密度;骨物理学指标和生物力学指标。结果与模型组比较,淫羊藿苷组可不同程度的升高血清中Ca2+、P3+浓度(P〈0.01),降低ALP(P〈0.01);升高骨中Ca2+、P3+、Hyp含量(P〈0.05或〈0.01);升高骨密度、湿重、干重(P〈0.01);增加骨中最大弯曲力、抗弯强度、断裂挠度、弹性段终点荷。结论淫羊蓉苷对维甲酸致大鼠骨质疏松有一定的防治作用。
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关 键 词: | 淫羊藿苷 维甲酸 骨质疏松 |
Effect of icariin on osteoporosis induced by retinoic acid in rats |
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Institution: | ZHU Guizhen, LIU Mingyu, SUN Lifeng, et al. Department of Osteology, Seaport Hospital of Qinhuangdao City, Hebei, Qinhnangdao 066000, China |
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Abstract: | Objective To investigate the effect of icariin on osteoporosis induced by retinoic acid in rats. Methods The rats were randomly divided into control group,model group and icariin tow -dose, middle -dose, high -dose group, with 10 rats in each group. The osteoporosis models in rats were established by giving icariin 70mg/kg via gavage for two weeks. The rats in icariin groups were given icariin 50,100,200mg by gavage, respectively for 4 weeks. The related indexes about blood and bone, bone density, bone physical and biomechanical parameters were detected. Results As compared with those in model group, the levels of Ca2 ~ , p3 ~ in serum were increased, however, the concentrations of ALP were decreased in icariin groups (P 〈 0. O1 ). The levels of Ca2+ ,p3+ ,Hyp in bone were increased ( P 〈0.05 or 〈0. O1 ) ,and bone density,wet weight,dry weight, maximum bending force, bending strength, bending strength, the end point of section elastic load in bone were increased in icariin groups ( P 〈 O. O1 ). Conclusion Icariin has preventive and the therapeutic effects at some extent on osteoporosis induced by retinoic acid in rats. |
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Keywords: | icariin retinoic acid osteoporosis |
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