| 川乌抗肿瘤初步研究 |
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| 引用本文： | 黄秀曼,刘迎辉,杜钢军. 川乌抗肿瘤初步研究[J]. 河南大学学报(医学版), 2014, 0(2): 82-84 |
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| 作者姓名： | 黄秀曼 刘迎辉 杜钢军 |
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| 作者单位： | 黄秀曼 (南阳市第一人民医院临床医学科，河南南阳473000 河南大学药学院药物研究所，河南开封475004)； 刘迎辉 (河南大学药学院药物研究所,河南开封,475004)； 杜钢军 (河南大学药学院药物研究所,河南开封,475004)； |
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| 基金项目： | 国家自然科学基金项目（81173094）;河南省高校青年骨干教师项目（2010GGJS-025）;河南省科技厅重点攻关项目（112101310308）;河南大学省部共建项目（SBGJ090704）. |
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| 摘 要： | 目的初步研究川乌的抗肿瘤作用。方法体内实验:建立小鼠肝癌H22皮下移植动物模型,灌胃给药后测定原位肿瘤体积、质量及免疫器官指数;体外实验:用MTT法测定川乌对小鼠Lewis肺癌细胞增殖的影响。结果体内实验:在本实验剂量下,与模型组比较,川乌组肿瘤生长减缓,抑瘤率为32.05﹪,胸腺指数、脾脏指数均升高;体外实验:实验所用浓度的川乌对小鼠肺癌细胞有生长抑制作用。结论川乌有一定抗肿瘤作用。
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| 关 键 词： | 川乌 H22 Lewis MTT |
Preliminary study of Radix Aconiti on anti-tumor |
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| HUANG Xiuman,LIU Yinghui,DU Gangjun. Preliminary study of Radix Aconiti on anti-tumor[J]. Journal of Henan University, 2014, 0(2): 82-84 |
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| Authors: | HUANG Xiuman LIU Yinghui DU Gangjun |
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| Affiliation: | 1 .The first people＇s hospital of Nanyang Department of Clinical medicine, Nanyang, Henan 473000 , China; 2 .Institute of Pharmacy, Pharmaceutical College of Henan University , Kaifeng, Henan 475004, China) |
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| Abstract: | Objective To study the anti-tumor of Radix Aconiti preliminarily . MethodsIn vivo , the model of H22 liver cancer was established to observe anti-tumor by measuring the volume , weight of in situ tumor and immune organs index after ig of Radix Aconiti medicinal liquor . In vitro , the effects of Radix Aconiti medicinal liquor on Lewis cells by MTT assay .Results In vivo , compared with the model group , the tumor in Radix Aconiti group was smaller , the tumor inhibitory rate was 32 .05% , both of thymus index and spleen index increased .In vitro ,Radix Aconiti medicinal liquor at used doses inhibited proliferation of lewis lung cancer cells . Conclusion Radix Aconiti medicinal liquor has beneficial effects on tumor treatment . |
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| Keywords: | Radix Aconiti H22 Lewis MTT |
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