| 紫锥菊提取物的遗传毒性试验研究简 |
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| 引用本文： | 于蒙,贺文庆,冯全利,陈秀云,卜仕金.紫锥菊提取物的遗传毒性试验研究简[J].黑龙江医学,2014,38(1):1-3. |
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| 作者姓名： | 于蒙 贺文庆 冯全利 陈秀云 卜仕金 |
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| 作者单位： | 于蒙 (徐州医学院,江苏徐州,221004)； 贺文庆 (扬州大学兽医学院,江苏扬州,225009)； 冯全利 (扬州大学兽医学院,江苏扬州,225009)； 陈秀云 (扬州大学兽医学院,江苏扬州,225009)； 卜仕金 (扬州大学兽医学院,江苏扬州,225009)； |
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| 摘 要： | 目的 研究紫锥菊提取物的遗传毒性,为紫锥菊的开发利用提供实验依据.方法按常规方法进行骨髓细胞微核试验、小鼠精子畸形试验和Ames试验.结果 紫锥菊提取物各剂量组与阴性对照组相比,差异无统计学意义（P＞0.05）,与阳性对照组相比,差异有统计学意义（P＜0.01）.结论 紫锥菊提取物对小鼠未见生殖遗传毒性,对鼠伤寒沙门氏菌无致突变性.
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| 关 键 词： | 紫锥菊提取物 微核试验 精子畸形试验 Ames试验 |
Experimental Research of Genetic Toxicity of Echinacea Purpurea Extraction |
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| Institution: | YU Meng,HE Wen-qing,FENG Quan-li(Xuzhou Medical College, Xuzhou 221004, CHINA) |
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| Abstract: | Objective To study genetic toxicity of the Echinacea purpurea extraction to provide experimental basis for Echinacea utili- zation. Methods Using standardized method to conduct marrow micronucleus test, mouse sperm abnormality test and Ames test. Results Echinacea extraction in each group was compared with the negative control group, with no statistical differences （P 〉 0. 05 ）. When com- pared with the positive control group, the differences was statistically significant （P 〈 0. 01 ）. Conclusion Echinacea purpurea extraction has neither genetic reproductive toxic effect on mice, nor mutagenicity on Salmonella typhimurium. |
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| Keywords: | Echinacea purpurea extraction Micronucleus test Sperm abnormality test Ames test |
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