Down-regulated VEGF expression in the diabetic heart is normalized by an endothelin ETA receptor antagonist |
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| Authors: | Jesmin Subrina Miyauchi Takashi Goto Katsutoshi Yamaguchi Iwao |
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| Affiliation: | Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. |
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| Abstract: | Recently, down-regulation of vascular endothelial growth factor (VEGF) in the heart was suggested as a potential molecular explanation for the increased risk of cardiovascular morbidity and mortality in patients with diabetes. Increased endothelin-1 production is reported in diabetes. Here, we report that down-regulated VEGF expression in the diabetic rat heart is normalized by an endothelin ETA receptor antagonist, suggesting that endothelin antagonism may be a novel therapeutic strategy for diabetic heart. |
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