Gamma-irradiation Sterilization in an Inert Environment: A Partial Solution |
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| Authors: | Daniel J. Berry Barbara H. Currier Michael B. Mayor John P. Collier |
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| Affiliation: | (1) Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA;(2) Dartmouth Biomedical Engineering Center, Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA; |
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| Abstract: | Background In the mid to late 1990s, to sterilize UHMWPE bearings, manufacturers changed from gamma-irradiation-in-air (gamma-air) sterilization, which initiated oxidation leading to bearing fatigue, to gamma-irradiation sterilization in an inert environment (gamma-inert). The change to gamma-inert sterilization reportedly prevented shelf oxidation before implantation but not in vivo oxidation. |
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