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Chronic lymphocytic leukaemia genetics overview
Authors:Caporaso Neil  Goldin Lynn  Plass Christoph  Calin George  Marti Gerald  Bauer Steven  Raveche Elizabeth  McMaster Mary Lou  Ng David  Landgren Ola  Slager Susan
Affiliation:Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. caporaso@nih.gov
Abstract:Although the familial aspect of chronic lymphocytic leukaemia (CLL) has been appreciated for decades, it is only with the recent confluence of improved molecular and gene technologies and world-wide collaborative networks that accelerated progress has become apparent. In this summary we highlight selected themes in the genetics of CLL emphasizing the opportunities and challenges of this malignancy.
Keywords:genetic association  linkage  susceptibility  candidate genes  chronic lymphocytic leukaemia  family studies
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