Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States) |
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| Authors: | David G. Cox Susan E. Hankinson David J. Hunter |
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| Affiliation: | (1) Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave., 02115 Boston, MA, USA;(2) Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA;(3) Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA |
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| Abstract: | AURKA is an important protein in the regulation of G2 to M transition during mitosis. Due to this regulatory function, it has been hypothesized to be a potential cancer susceptibility gene. Two non-synonymous polymorphisms (F31I and V57I) have been associated with breast cancer risk in prior studies. We sought to confirm these findings in a large case control study nested within a prospective cohort, the Nurses' Health Study. Post-menopausal women who were homozygous for the 31I and 57V alleles had an increased risk of invasive breast cancer (OR 1.63, 95% CI 1.08–2.45). We also performed a meta-analysis to summarize the findings of this and prior studies of association between the F31I polymorphism and breast cancer risk (Summary OR 1.29, 95% CI 1.08–1.53, p-heterogeneity = 0.29). These results confirm prior findings that AURKA represents a low penetrance breast cancer susceptibility gene. |
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| Keywords: | Aurora kinase AURKA Breast cancer SNP |
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