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| 肝细胞生长因子对慢性肝损伤时肝部分切除术后肝再生和肝功能的影响 | |
| 引用本文： | 左国杰,杨立群,文莉,陈光,张福君. 肝细胞生长因子对慢性肝损伤时肝部分切除术后肝再生和肝功能的影响[J]. 中国实验诊断学, 2005, 9(4): 544-545 |
| 作者姓名： | 左国杰 杨立群 文莉 陈光 张福君 |
| 作者单位： | 1. 深圳市福田区中医院,外科,广东,深圳,518034 2. 吉林大学第一临床医院,普外科 3. 中山大学肿瘤医院,介入科 |
| 摘 要： | 目的研究肝细胞生长因子对慢性肝损伤时肝部分切除术后肝再生和肝功能的影响。方法对慢性肝损伤模型SD大鼠行30%肝部分切除术,术后10d,经腹腔注射肝细胞生长因子,同时建立正常对照组。观察不同剂量肝细胞生长因子对肝再生,肝功能和肝储备功能的影响。结果实验组与对照组相比,AST,ALT,总胆固醇、动脉血酮体比具有显著的统计学意义(P<0.01)。结论应用外源性肝细胞生长因子可明显改善肝功能和肝储备功能,促进肝细胞再生。 |
| 关 键 词： | 肝细胞生长因子 慢性肝损伤 肝功能 肝再生 |
| 文章编号： | 1007-4287(2005)04-0544-02 |
| 收稿时间： | 2004-12-12 |
| 修稿时间： | 2004-12-12 |
The influence of hepatocyte growth factor on regeneration and function of liver after hepatectomy |
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| Zuo GuoJie;Yang LiQun;Wen Li;Chen Guang;Zhang FuJun. The influence of hepatocyte growth factor on regeneration and function of liver after hepatectomy[J]. Chinese Journal of Laboratory Diagnosis, 2005, 9(4): 544-545 | |
| Authors: | Zuo GuoJie Yang LiQun Wen Li Chen Guang Zhang FuJun |
| Abstract: | ObjectiveTo study the influence of hepatocyte growth factor on regeneration and function of liver after hepatectomy. Methods30% hepatectomy was performed on SD rats. Hepatocyte growth factor was administered by infusion into intro-abdomen on the 10th day after hepatectomy. ResultsLiver regeneration and enhance liver function could be found in rats treated with hepatocyte growth factor. ConclusionHepatocyte growth factor enhances the growth and function of the remnant liver in rats with cirrhosis after partial hepatectomy. |
| Keywords: | hepatocyte growth factor chronical hepatectomy liver funtion liver regeneration |
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