不同类型腹膜炎内毒素血症形成的实验研究

本实验通过建立无菌和有菌两类实验性急性腹膜炎的大鼠模型，分别在不同时间测定其心血内毒素含量，从而分析在不同类型腹膜炎时内毒素血症的形成机制。结果表明两类腹膜炎的心血内毒素含量均高于正常值（Ｐ＜０．０１）。从而说明无论是细菌性或化学性腹膜炎，只要腹腔出现炎性反应则会使血中内毒素含量明显增加，任何种腹膜炎皆可使肠壁发生病理变化而使肠源性内毒素大量入血．而细菌性腹膜炎又有腹腔感染细菌所产生的内毒素入血，因此血中内毒素含量更有所增高。本实验证明急性腹膜炎血中内毒素来源，除来自感染病灶外，肠源性内毒素是一重要来源。

EXPERIMENTAL ENDOTOXEMIA MODEL IN DIFFERENT TYPES OF PERITONITIS

The experimental endotoxemia model in different types of peritonitis was established in 48 rats. The authors used 12 rats to measure the endotoxin levels in normal intracardiac blood. The other 36 rats were divided into three groups (12 rats in a group).One group was made into the moder of fecal peritonitis, another group the model of chemical peritonitis, and the third group was the control. The authors sampled the intracardiac blood at 1, 2, 4, and 8 hours after operation to determine the endotoxin levels. The results showed that the endotoxin levels were higher in the fecal peritonitis group than in the chemical peritonitis group, and the endotoxin levels of the groups mentioned above were significantly higher than those of the control group. It is indicated that during the acute bacterial peritonitis the endotoxin of blood was originated from the peritoneal focus and the intestine.