| 黄芪总皂苷和赤芍总苷协同抗血小板作用研究 |
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| 引用本文： | 徐先祥,夏伦祝,高家荣,刘青云,彭代银.黄芪总皂苷和赤芍总苷协同抗血小板作用研究[J].中药材,2002,25(9):653-655. |
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| 作者姓名： | 徐先祥 夏伦祝 高家荣 刘青云 彭代银 |
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| 作者单位： | 1. 安徽中医学院第一附属医院,合肥,230031
2. 安徽中医学院,合肥,230038 |
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| 摘 要： | 目的:观察黄芪总皂苷和赤芍总苷(1:3)(简称芪芍双苷)的抗血小板作用。方法:芪芍双苷按100、200、400mg/kg三种剂量给药,进行了血小板聚集试验,测定了大鼠血浆中血小板α颗粒胰蛋白-14O(GMP-14O)含量及血栓素A_2(TXA_2)/前列环素(PGI_2)水平。结果:芪芍双苷三种剂量均能抑制 ADP诱导的血小板聚集,明显降低GMP-140含量,显著降低TXA_2/PGI_2比值。结论:芪芍双苷具显著抗血小板作用。
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| 关 键 词： | 黄芪总皂苷 赤芍总苷 血小板α颗粒膜蛋白-140(GMP-140) 血栓素A_2(TXA_2) 前列环素(PGI_2) |
| 修稿时间： | 2002年4月2日 |
Study on Antiplatelet Effect of Radix Astragali Total Saponin Combined with Radix Paeoniae Rubra Giucosides |
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| Xu Xianxiang,Xia Lunzhu,Gao Jiarong.Study on Antiplatelet Effect of Radix Astragali Total Saponin Combined with Radix Paeoniae Rubra Giucosides[J].Jorunal of Chinese Medicinal Materials,2002,25(9):653-655. |
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| Authors: | Xu Xianxiang Xia Lunzhu Gao Jiarong |
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| Institution: | First Affiliated Hospital of Anhui College of TCM, Hefei 230031. |
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| Abstract: | Objective:To research effects of Radix Astragali total saponin combined with Radix Paeoniae Rubra glucosides (double gluco-sides of Qi-Shao, DGQS) on antiplatelet. Methods: Antiplatelet effect of DGQS at three dosages (100 mg/kg, 200 mg/kg, 400 mg/kg) were studied. And levels of granule membrane protein 140 (GMP-140), TXA2 and PGI2 in rat plasma were determined. Results: DGQS as whole could restrain platelet aggregation, decrease content of GMP-140, bring down level of TXA2/PGI2. Conclusion: DGQS had apparent antiplatelet effect. |
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| Keywords: | Radix Astragali total saponin Radix Paeoniae Rubra glucosides GMP-140 TXA2 PGI2 |
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