RETRACTED ARTICLE: Effects of dobutamine on the fatigued diaphragm: A comparison with dopamine |
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Authors: | Yoshitaka Fujii Tomoyuki Udagawa Hidenori Toyooka |
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Institution: | (1) Department of Anesthesiology, Toride Kyodo General Hospital, 5901-1, Terada, 302 Toride City, Ibaraki, Japan;(2) Department of Anesthesiology and Critical Care Medicine, Tokyo Medical and Dental University School of Medicine, 1-5-45 Yushima, Bunkyo-ku, 113 Tokyo, Japan |
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Abstract: | We examined the effects of dopamine (DOA) 10 μg·kg−1·min−1 I.V. and dobutamine (DOB) 10 μg·kg−1. min−1 I.V. on the contractility of the fatigued diaphragm in 26 anesthetized, mechanically ventilated dogs. Animals were divided
into two groups of 13 each: the DOA and DOB groups. Diaphragmatic fatigue was induced by intermittent supramaximal bilateral
electrophrenic stimulation at a frequency of 20 Hz applied for 30 min. Diaphragmatic contractility was assessed from changes
in transdiaphragmatic pressure (Pdi). After diaphragmatic fatigue, Pdi at low-frequency (20 Hz) stimulation decreased significantly compared with the prefatigue value (P<0.05), whereas no change in Pdi was observed at high-frequency (100 Hz) stimulation. In the fatigued diaphragm, Pdi at both stimuli increased with an infusion of either DOA (P<0.05) or DOB (P<0.05). The increase of Pdi at 20 Hz stimulation was significantly larger in the DOB group compared with that of the DOA group (P<0.05). In each group, Pdi at both stimuli decreased after the cessation of administration. The integrated diaphragmatic electric activity (Edi) in the two groups did not change at any frequency of stimulation throughout the study. We conclude that DOB in comparison
with DOA is more effective in improving the contractility of the fatigued diaphragm. |
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Keywords: | Diaphrmagmatic fatigue Transdiaphragmatic pressure Dopamine Dobutamine |
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