| NIDDM合并视网膜病变患者红细胞聚集性变化及其影响因素 |
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| 引用本文： | 张学亮 何作云. NIDDM合并视网膜病变患者红细胞聚集性变化及其影响因素[J]. 中国血液流变学杂志, 1997, 7(3): 12-14 |
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| 作者姓名： | 张学亮 何作云 |
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| 摘 要： | 本文测定了 ＮＩＤＤＭ合并视网膜病变患者２１例、无视网胰病变患 者１９例及正常对照２０例的红细胞聚集性有关参数。的果显示，ＮＩＤＤＭ视网膜病 变组的低切全血粘度、红细胞聚集指数均显著高于无视网膜病变组及对照组（Ｐ＜ ０．０１）。ＮＩＤＤＭ组和合并视网膜病变组的血沉及血沉方程Ｋ值均显著高于对照组 （Ｐ＜０．０１）。ＮＩＤＤＭ视网膜病变组的血浆纤维蛋白原水平及糖化血清蛋白指数 均显著高于无视网膜病变组和对照组（Ｐ＜０．０５，Ｐ＜０．０１）。ＮＩＤＤＭ视网膜病变 组血清白蛋白及超氧化物歧化酶（ＳＯＤ）均显著低于无视网膜病变组和对照组（Ｐ ＜０．０５，Ｐ＜０．０１）．ＮＩＤＤＭ视网膜病变组红细胞聚集指数与血浆纤维蛋白原、 糖化血清蛋白指数呈显著正相关（ｒ值 ０．４５２、０．４４６，Ｐ＜０．０５）．与血清ＳＯＤ、白蛋 白呈显著负相关（ｒ－０．４６２、－０．４３９，Ｐ＜０．０５）．结果提示，ＮＩＤＤＭ合并视网膜 病变患者上细胞聚集性增高，这种增高与血中纤维蛋白原水平增高，蛋白质非酶糖 基化增加、ＳＯＤ及白蛋白水平降低有关．
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| 关 键 词： | 红细胞聚集性 糖尿病性视网膜病变 NIDDM |
ALTERATION OF ERYTHROCYTE AGGREGATION IN NIDDM PATIENTS WITH RETINOPATHY |
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| Zhang Xueliang et al. ALTERATION OF ERYTHROCYTE AGGREGATION IN NIDDM PATIENTS WITH RETINOPATHY[J]. Chinese Journal of Hemorheology, 1997, 7(3): 12-14 |
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| Authors: | Zhang Xueliang et al |
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| Affiliation: | Zhang Xueliang et al Department of Internal Medicine,Xinqiao Hospital,Third Military Medical University,Chongqing |
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| Abstract: | The paremetnts related with erythrocyte aggregation were measured in 21 non- insulin dependent diabetic(NIDDM ) patients with diabetic retinopathy as compared with 19 NIDDM patients without retinopathy and 20 normal subjects. The blood viscosity at low shear rate(5. 76S-1) ,erythrocyte aggregation index, plasma fibrogen and non - enzyme glycosylated serum protein index of NIDDM patints with retinopathy were significantly higher than those of control subjects and NIDDM patients without retinopathy(P < 0.01). with other paremenrts ,the result suggested that erythrocyte aggregation increases in NIDDM patients with retinopathy and the increase is related with increase of fibrogen and non -enzyme glycosylated serum protein and decrease of serum superoxide dismutase and albumin. |
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| Keywords: | Erythrocyte aggregation Diabetic retinopathy NIDDM |
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