银杏达莫注射液辅助治疗慢性肺源性心脏病急性加重期疗效观察

目的观察银杏达莫注射液治疗慢性肺源性心脏病心力衰竭患者的疗效及血液流变学改变。方法将心功分级（NYHA）均为Ⅳ级的慢性肺源性心脏病急性加重期患者103例，随机分为两组，对照组51例，予常规综合治疗。治疗组52例加用银杏达莫注射液20ml滴注，1次／d，14d为1疗程。结果治疗组显效27例（51.9％），有效20例（38.5％），无效5例（9.6％），总有效率90.4％。对照组显效22例（43.1％），有效18例（35.3％），无效11例（21.6％），总有效率78.4％。治疗组总有效率及显效率均优于对照组（P〈0.05）。两组治疗前血液粘滞度各项参数差异均无统计学意义（P〉0.05），治疗组治疗前后差异有统计学意义（P〈0.05），对照组治疗前后无统计学意义（P〉0.05）。结论在常规综合治疗基础上辅以银杏达莫注射液治疗慢性肺源性心脏病急性加重期心力衰竭可降低血液粘度，提高疗效，改善心功能，改善预后。

The therapeutic effect of gingko dipyridamole in jection in treating patients with acute exacerbation of chronic cor pulmonale

Objective To obverse the therapeutic effect of gingko dipyridamole injection in treating patients with acute exacerbationof chronic cor plumonale and the changes of haemrheology parameters after the treatment. Methods 103 patients suffered from acute exacerbationof chronic cor pulmonale （ all patients whose cardiac exercise class grade were four grade accord- ing to NYHA class）were divided into two groups randomly, the control group with 51 patients recieved the routine therepy for forteen days, the therapeutic group inluding 52 patients besides receiving routine therapy, were adminsisted the dosage of 20 ml gingko dipyridamole ingection once a day for forteen days. Results There were 27 patients woth excellenc effect,20 patients with good effect and tive patients without effect after treatment with the gingko dipyridamole injection,The tatal effective rate was 90.4% in the therapitc group. There were 22 patients woth excell enc effect, 18 patients with good eeffect and 11 patients without effect after treatment with the routine therapy, The total effective rate was 78.4% in the control group. The total effective rate and excelence effective rate in the gingko dipyridamole group were higher than than in the control group（ P〈0.05）. There were no difference in the parameters of haemorheology between two groups before therapy（P〉0.05）. The parameters of haemorheology were improved remarkablly in the gingko dipyrida mole group after therapy（ P〈0.05）, but the parameters of haemorheology withou any improvement in the control group after therapy with the rountine treatment （P〉0.05）. Conclusion The gingko dipyridmaote injection, above the routine combined therapy , applied to treat patients with acute exacerbationof chronic cor pulmonale, may reduce blood apparent visocity, increase therapeutic effect, improve heart function and prognosis of chronic cor pulmonale.