Kigamicins, novel antitumor antibiotics. I. Taxonomy, isolation, physico-chemical properties and biological activities |
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Authors: | Kunimoto Setsuko Lu Jie Esumi Hiroyasu Yamazaki Yohko Kinoshita Naoko Honma Yoshiko Hamada Masa Ohsono Michiyo Ishizuka Masaaki Takeuchi Tomio |
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Affiliation: | Microbial Chemistry Research Center, Numazu Bio-Medical Research Institute, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan. kunimotos@bikaken.or.jp |
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Abstract: | Novel antibiotics named kigamicin A, B, C, D, and E were discovered from the culture broth of Amycolatopsis sp. ML630-mF1 by their selective killing activity against PANC-1 cells only under a nutrient starved condition. Under a condition of nutrient starvation, kigamicins A, B, C, and D inhibited PANC-1 cell survival at 100 times lower concentration than in normal culture. Kigamicins showed antimicrobial activity against Gram-positive bacteria including methicillin resistant Staphylococcus aureus (MRSA). Kigamicin D inhibited the growth of various mouse tumor cell lines at IC50 of about 1 microg/ml. |
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