| 血管内皮细胞生长因子与P53在卵巢上皮性肿瘤中表达的定量分析 |
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| 引用本文： | 王珏辉,郭宇红,张红新,宋一民,高冬玲. 血管内皮细胞生长因子与P53在卵巢上皮性肿瘤中表达的定量分析[J]. 现代预防医学, 2010, 37(10) |
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| 作者姓名： | 王珏辉 郭宇红 张红新 宋一民 高冬玲 |
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| 作者单位： | 1. 郑州铁路职业技术学院护理系,郑州,450052
2. 郑州大学第一附属医院病理科,河南省肿瘤病理重点实验室 |
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| 摘 要： | [目的]定量比较血管内皮细胞生长因子(VEGF)与P53蛋白在卵巢上皮性肿瘤中的表达的差别和关系。[方法]用细胞图象分析技术和免疫组化法分别检测VEGF和P53蛋白在61例上皮性卵巢良恶性肿瘤组织中表达的积分吸光度(IA)和平均吸光度(MA)。[结果]良性、交界性及恶性肿瘤组织中VEGF和P53蛋白表达的IA与MA值依次增大,良性肿瘤、交界性肿瘤和恶性肿瘤分别两两相比,其IA和MA值差异有统计学意义(P﹤0.01)。VEGF表达与P53蛋白表达结果相互间有联系(P﹤0.05)。[结论]VEGF和P53蛋白在上皮性卵巢肿瘤的形成和发展中有重要影响,可以作为卵巢肿瘤生物学行为恶化的一项指标。
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| 关 键 词： | 血管内皮生长因子 P53 卵巢上皮性肿瘤 免疫组织化学 定量分析 |
QUANTITATIVE MORPHOLOGICAL STUDY ON THE EXPRESSION OF VEGF AND P53 IN OVARIAN EPITHELIAL TUMORS |
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| WANG Jue -hui,GUO Yu -hong,ZHANG Hong -xin,et al.. QUANTITATIVE MORPHOLOGICAL STUDY ON THE EXPRESSION OF VEGF AND P53 IN OVARIAN EPITHELIAL TUMORS[J]. Modern Preventive Medicine, 2010, 37(10) |
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| Authors: | WANG Jue -hui GUO Yu -hong ZHANG Hong -xin et al. |
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| Affiliation: | WANG Jue -hui,GUO Yu -hong,ZHANG Hong -xin,et al.(Zhenzhou Railwany Vocational College,Zhengzhou 450052,China) |
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| Abstract: | [Objective] To investigate quantitatively the differences and relationship between expressions of vascular endothelial growth factor (VEGF) and P53 protein in ovarian epithelial tumors (OET). [Methods] The quantitative parameters were examined by means of Image Analysis System. 61 cases of OET tissues were stained in VEGF antigen and P53 protein by SP immunohistochemical method. [Results] The integral optical density (IOD) and the mean optical density (MOD) of VEGF and P53 expressions were more and more inc... |
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| Keywords: | VEGF P53 Ovarian epithelial neoplasm Immunohistochemitry Quantitative analysis |
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