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| 狼疮性肾炎肾组织中骨调素的研究 | |
| 引用本文： | 李龙,陈运芬,陈艳,陈永雄,余学清,尹培达,罗建华. 狼疮性肾炎肾组织中骨调素的研究[J]. 贵阳医学院学报, 2002, 27(3): 196-199 |
| 作者姓名： | 李龙 陈运芬 陈艳 陈永雄 余学清 尹培达 罗建华 |
| 作者单位： | 1. 贵阳医学院附院肾内科,贵州贵阳,55004 2. 遵义县新舟镇医院,贵州遵义,563127 3. 中山医科大学附一院肾内科,广州3510080 |
| 基金项目： | 贵州省卫生厅青年基金资助项目 |
| 摘 要： | 目的：探讨骨调素（OPN）在狼疮性肾炎（LN）肾组织中的表达及意义。方法：用微波免疫组化双重染色法观察肾组织OPN蛋白的表达，用原位杂交检测肾组织OPN mRNA的表达，并监测肾功能相关指标。结果：LN肾小管OPN mRNA及蛋白表达较对照组明显增高。结论：OPN与LN肾功能损害正相关。 |
| 关 键 词： | 狼疮肾炎 肾小管 免疫组织化学 原位杂交 骨调素 OPN LN |
| 文章编号： | 1000-2707(2002)03-0196-04 |
| 修稿时间： | 2002-01-16 |
A Research on Osteopontin in Kidney Tissue of Patients with Lupus Nephritis |
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| LI Long ,CHEN Yun fen ,CHEN Yan ,CHEN Yong xiong ,YU Xue qing ,YIN Pei da ,LUO Jian hua. A Research on Osteopontin in Kidney Tissue of Patients with Lupus Nephritis[J]. Journal of Guiyang Medical College, 2002, 27(3): 196-199 | |
| Authors: | LI Long CHEN Yun fen CHEN Yan CHEN Yong xiong YU Xue qing YIN Pei da LUO Jian hua |
| Affiliation: | LI Long 1,CHEN Yun fen 1,CHEN Yan 2,CHEN Yong xiong 3,YU Xue qing 3,YIN Pei da 3,LUO Jian hua 1 |
| Abstract: | Objective:To investigate the expression and clinical significance of osteopontin (OPN) in the kidney tissue of Lupus Nephritis (LN) patients. Methods: The expression of OPN and KP1 (rat antihuman macrophage monoclonal antibody) was detected with microwavebased double labelled immunostaining.The expression of OPN mRNA was detected with in situ hybridization. The relative index of renal function of patients were examined. Results:The OPN Protein and OPN mRNA expressions of LN patients were higher than those of normal group in the tubulointerstitial area. Conclusion: OPN showed a positive correlation with renal lesions in LN. |
| Keywords: | lupus nephritis kidney tubules immunohistochemistry in situ hybridization osteopontin |
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