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On the mechanism of drug-induced gingival hyperplasia |
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| Authors: | Ronald S. Brown William T. Beaver William K. Bottomley |
| Affiliation: | Department of Oral Diagnostic Sciences, University of Texas, Houston. |
| Abstract: | Proposed mechanisms of the side effect of drug-induced gingival hyperplasia are reviewed. Hypotheses with regard to inflammation from bacterial plaque, increased sulfated glycosaminoglycans, immunoglobulins, gingival fibroblast phenotype population differences, epithelial growth factor, pharmacokinetics and tissuebinding, collagenase activation, disruption of fibroblast cellular sodium/calcium flux, folic acid and a combination hypothesis are evaluated. |
| Keywords: | calcium collagenase cyclosporine diltiazem drug side effect folate gingival fibroblasts gingival hyperplasia gingival overgrowth nifedipine nitrendipine phenytoin verapamil |