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Clinical importance of precursor lesions in the pancreas
Authors:Hruban Ralph H  Takaori Kyoichi  Canto Marcia  Fishman Elliot K  Campbell Kurtis  Brune Kieran  Kern Scott E  Goggins Michael
Institution:(1) Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Weinberg Room 2242, 401 North Broadway, Baltimore, MD, USA;(2) Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Weinberg Room 2242, 401 North Broadway, Baltimore, MD, USA;(3) Department of General and Gastroenterological Surgery, Osaka Medical College, Osaka, Japan;(4) Department of Medicine, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Weinberg Room 2242, 401 North Broadway, Baltimore, MD, USA;(5) Department of Radiology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Weinberg Room 2242, 401 North Broadway, Baltimore, MD, USA;(6) Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Weinberg Room 2242, 401 North Broadway, Baltimore, MD, USA
Abstract:Three distinct noninvasive precursor lesions to invasive ductal adenocarcinoma of the pancreas have been described. These include the mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia. The early detection and treatment of these lesions can interrupt the progression of a curable noninvasive precursor to an almost uniformly deadly invasive cancer.
Keywords:Pancreas  Cancer  Precursor  Intraductal papillary mucinous neoplasm  Pancreatic intraepithelial neoplasia  Mucinous cystic neoplasm
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