| 丝裂霉素、5-氟尿嘧啶、三苯氧胺联合应用对人乳癌细胞株的作用 |
| |
| 引用本文： | 苏新良,吴凯南,唐俐. 丝裂霉素、5-氟尿嘧啶、三苯氧胺联合应用对人乳癌细胞株的作用[J]. 现代医药卫生, 2003, 19(8): 949-950 |
| |
| 作者姓名： | 苏新良 吴凯南 唐俐 |
| |
| 作者单位： | 重庆医科大学附属第一医院,重庆,400016 |
| |
| 摘 要： | 目的：观察丝裂霉素、5-氟尿嘧啶、三苯氧胺联合应用对人乳腺癌细胞株(MDA—MB—435S)的相互作用。方法：采用MTT法利用中效原理判断联合用药的效应。结果：MMC、5—Fu单用及联合应用时，随着药物浓度增加其效应也增加；TAM与MMC、5—Fu合用时，对MDA—MB—435S细胞作用不明显；MMC与5—Fu高浓度合用时呈协同作用，低浓度时呈拮抗作用；两药合用时浓度比例变化及给药时间次序对效应影响不大。结论：MMC与5—Fu高浓度合用时为协同作用，低浓度时为拮抗作用。TAM与MMC、5—Fu合用时，对MDA—MB—435S细胞作用不明显。两药合用效应大小与两药浓度比例及给药时向次序无关。
|
| 关 键 词： | 乳腺癌 药物疗法 丝裂霉素 5-氟尿嘧啶 三苯氧胺 |
| 文章编号： | 1009-5519(2003)08-0949-02 |
| 修稿时间： | 2003-02-27 |
The interaction between metomycin, 5 - fluorouracil and tamosifen on human breast cancer cell line(MDA-MB - 435S). |
| |
| SU Xin-liang,WU Kai-lan,TANG Li. The interaction between metomycin, 5 - fluorouracil and tamosifen on human breast cancer cell line(MDA-MB - 435S).[J]. JOURNAL OF MODERN MEDICINE & HEALTH, 2003, 19(8): 949-950 |
| |
| Authors: | SU Xin-liang WU Kai-lan TANG Li |
| |
| Affiliation: | SU Xin-liang,WU Kai-lan,TANG Li.Department of General Surgery,First Affiliated Hospital of Chongqing Medical University Chongqing 400016. |
| |
| Abstract: | Objective: To evaluate the killing effects of MMC, 5 - Fu and TAM on human breast cancer cell line(and MDA-MB-435S) .Methods: The median - effect principle was used. Results: Killing effects of the individual drugs were enhanced as median concentration increased. We also observed that the interaction of drugs was synergy at higher concentration (CI< 1) . Finally, both the ratios of drug concentration and the sequence of administration were not related with the killing effects. Concluion: The interaction of drugs was synergy at higher concentration.The drug administration order and drug concentrations are not related with the killing effects. |
| |
| Keywords: | Metomycin 5 ~ Fluorouracil Tamosifen Median - effect principle Combination index(CI) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
