运动抑制内皮剥脱后血管内膜增殖反应的作用及机制

本实验采用大鼠球囊内皮剥脱模型研究表明，内皮损伤后可导致内膜增厚，但内皮损伤后每日游泳６０分钟，共游泳２周，大鼠组比内皮损伤后非游泳组内膜增生厚度、面积和细胞数分别降低了５４．７％，４８．７％和５１．５％（Ｐ＜０．０１）；动脉血管环对ＡＣＨ的舒张反应性提高（Ｐ＜０．０１）；血管组织ｃＧｍＰ水平提高５８．３％（Ｐ＜０．０１）。提示运动可明显抑制动脉内皮损伤后增殖反应的第１、２高峰期；血管内皮释放内皮舒张因子增多可能是运动抑制内皮损伤后增殖反应的机制之一。

Effect of Exercise on Intimal Proliferation of the Injured Vessel Intima and lts Mechanism in Rats

Effect of exercise on intimal proliferation of the injured vessel wall was studied by the carotid utery balloon injury model in rats . 20 rats were divided into sedentary control group(n=6) . injured vessel wall group( n= 6 ) and swimming exerciae group following veasel wall injured ( n= 8 ) . The reaults showed that the prolifemus area , thickneas and cell nurnber of intima were reduced by 48.7% 54.7% reapectively , the vasodilator reaponsea to Ach was increased obvi- ously and cGMP level of the injured artery was enhanced by 58.3% in exercise group swimming for 2 weeks following vessel injured , compared with injured vessel group( P<0. 01 ) . These results suggested that the first and second intimal prolierous waves were inhibited and vasodilation response of vessel injured was enhanced by exercise . The results also suggeated that exercise-induced EDRF release may play a significant role in exercise preventing intimal proliferation of the injured vessel wall.