胃癌组织中HGF、c-Met的表达及意义

 目的 探讨HGF和c-Met的表达与胃癌临床病理生物学行为的关系以及它们之间的相关性。 方法 应用免疫组化方法检测52例胃癌患者癌组织中HGF、c-Met的表达。 结果 HGF的表达与组织学分级、浸润深度、临床分期、淋巴结转移显著相关（P＜0.05），与年龄、肿瘤大小无关（P＞0.05）。c-Met的表达与组织学分级及淋巴结转移密切相关，而与肿瘤大小、年龄、浸润深度、临床分期无关（P＞0.05）。且两者表达呈正相关（r=0.342，P＜0.05）。 结论 HGF及c-Met促进了胃癌组织的生长与转移，具有协同作用，可作为胃癌的预后评估因子。

Expression and Prognostic Significance of HGF/c-Met in Gastric Carcinoma

Objective To detect the association of the expressive levels of hepatocyte growth factor and c-Met with the clinicobiologic behavior in gastric carcinoma and the correlation between these two factors. Methods Immunohistochemistry method was used to detect the expression of HGF and c-Met in gastric cancer and normal tissues near the tumor borderline. Results The expression of HGF had the positive correlation with histologic types, infiltration depth, clinical stage and lymph node metastasis (P<0.05). No correlation was found in age or tumor diameter(P>0.05). The expression of c-Met had the positive correlation with histologic types and lymph node metastasis (P<0.05). No correlation was found in age, tumor diameter, infiltration depth and clinical stage (P>0.05). And HGF had a positive correlation with c-Met in gastric cancer(r= 0.342,P<0.05). Conclusion HGF and c-Met may improve the growth and metastasis of gastric carcinoma. They could be prognostie markers for gastric carcinoma.