美金刚联合丁苯酞治疗血管性痴呆临床疗效观察

目的：观察美金刚（易倍申）和丁苯酞（恩必普）对血管性痴呆（Va D）患者认知和行为功能障碍的改善作用及安全性。方法：将40例Va D患者随机分为美金刚联合丁苯酞治疗组22例（联合治疗组）和美金刚治疗组18例（对照组）。2组患者分别在治疗前和治疗3个月、6个月进行简易精神状态检查（MMSE）以及日常生活能力（ADL）的测评,比较2组的评分结果,并观察不良反应。结果：联合治疗组患者3个月和6个月ADL评分分别为（25.2±5.4）分和（23.2±5.6）分,MMSE评分分别为（18.8±4.4）分和（20.1±4.8）分;对照组患者3个月和6个月ADL评分分别为（26.6±5.9）分和（25.4±6.1）分,MMSE评分分别为（18.1±4.9）分和（18.9±4.7）分。2组与治疗前相比差异均有统计学意义（均P〈0.05）。2组间治疗后6个月比较差异有统计学意义（P〈0.05）。2组均未出现严重不良反应。结论：美金刚和丁苯酞联合应用对Va D的认知功能、行为能力改善效果较单用美金刚明显,并具有较高的安全性。

Clinical research of combination of memantine and butylphthaliden in the treatment of patinta with vas- cular dementia

Objective： To observe the curative effect and safety of combination of memantine and bu-tylphthalide in the treatment of vascular dementia （VaD）, the improvement of the cognitive function and behav- ioral capacity. Methods： Forty cases with VaD were randomly divided into 2 groups： one group treated with memantine and butylphthalide, the other group treated with memantine. MMSE scale and ADL scale of 2 groups were assessed and compared the pre-treatment with the treatment in 3 months, 6 months later. A comparative study was made to evalate the curative effects and side effects between 2 groups. Results： After treating with me- mantine and butylphthaliden for 3 months and 6 months, the ADL scores were （25.2±5.4） and （23.2±5.6） respec- tively, MMSE scores were （18.8±4.4） and （20.1±4.8） respectively. After treatment with memantine for 3 months and 6 months, the ADL scores were （26.6±5.9） and （25.4±6.1） respectively, MMSE scores were （18.1±4.9） and （18.9±4.7） respectively. The data compared pre-treatment with the two groups had statistical significance （P〈0.05）. The scores of MMSE and ADL after 6 months treatment between two groups have statistical signifi- cance （P〈0.05）. No serious adverse events was recorded during treatment. Conclusion： Combination of meman- tine and butylphthalide can markedly ameliorate the cognitive function and behavioral abilities in patients with vascular dementia. Its combination with butylphthalide is superior to its single use with high safety.