γ干扰素诱导蛋白10（IP-10）对糖尿病合并活动性肺结核的临床诊断价值

目的探讨γ干扰素诱导蛋白10（IP-10）对糖尿病合并活动性肺结核的临床诊断价值。方法选取糖尿病合并活动性肺结核病例（A组）24例、活动性肺结核病例（B组）34例、非结核肺部疾病病例（C组）10例、糖尿病（D组）10例、健康志愿者（E组）12例，检测血IP-10水平。结果A组IP-10水平均高于其他4组（P均〈0．01）；IP-10诊断活动性肺结核的曲线下面积为0．872，临界值为146．80ng／L，敏感性和特异性分别为65．5％和93．7％。结论血IP-10在糖尿病合并活动性肺结核患者中显著增高，可作为其诊断的辅助指标。

Clinical significance of interferon - inducible protein - 10 in the diagnosis of diabetes and active tuberculosis

Objective To investigate the value of interferon - inducible protein - 10 （ IP - 10） in clinical diagnosis of diabetes and active tuberculosis. Methods 24 patients with diabetes and active tuberculosis （group A）, 34 patients with active tuberculosis （group B）, 10 patients with non -tuberculosis pulmonary disease （group C）, 10 patients with diabetes （group D）, and 12 healthy volunteers （group E） were enrolled for serum IP - 10 detection and statistical analysis. Results The serum IP - 10 concentrations in group A were significantly higher than the other 4 groups （P 〈 0.01 ）. In addition, when diagnosing active tuberculosis with IP - 10, the area under curve （AUC） was 0.872, the critical value was 146.80 ng/L. The sensitivity and specificity were 65.5% and 93.7%, respectively. Conclusions Serum IP - 10 is significantly increased in patients with diabetes and active tuberculosis, thus, IP - 10 can be used as an auxiliary index in the diagnosis of diabetes and active tuberculosis.