| 多组学网络背景下方剂临床价值的考量 |
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| 引用本文： | 李兵,韩飞,王忠,王永炎.多组学网络背景下方剂临床价值的考量[J].中国中药杂志,2017,42(5):848-851. |
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| 作者姓名： | 李兵 韩飞 王忠 王永炎 |
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| 作者单位： | 中国中医科学院 中医临床基础医学研究所, 北京 100700;中国中医科学院 中医药信息研究所, 北京 100700,北京中医药大学第三附属医院, 北京 100029,中国中医科学院 中医临床基础医学研究所, 北京 100700,中国中医科学院 中医临床基础医学研究所, 北京 100700 |
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| 基金项目： | 国家食品药品监督管理总局课题（CFDA H201501） |
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| 摘 要： | 临床价值评估是破解当前中成药(方剂)同品种重复率高、临床定位模糊、适应症宽泛、临床价值不清晰等诸多问题的关键所在。该文简要分析了当前方剂临床价值评估所面临的挑战和机遇,提出了多组学网络背景下的方剂研究策略。通过对中风病类方的比较分析,提示了3个方剂针对中风病不同症状(表型)的特色优势,为临床用药提供参考。多组学网络分析策略为方剂的临床价值评估与比较开辟了新的视角。
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| 关 键 词： | 多组学 中药复方 临床价值 网络分析 |
| 收稿时间： | 2017/2/10 0:00:00 |
Clinical value evaluation of Chinese herbal formula in context of multi-omics network |
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| LI Bing,HAN Fei,WANG Zhong and WANG Yong-yan.Clinical value evaluation of Chinese herbal formula in context of multi-omics network[J].China Journal of Chinese Materia Medica,2017,42(5):848-851. |
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| Authors: | LI Bing HAN Fei WANG Zhong and WANG Yong-yan |
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| Institution: | Institute of Clinical Basic Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Traditioanal Chinese Medicine Information Research, China Academy of Chinese Medical Sciences, Beijing 100700, China,The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China,Institute of Clinical Basic Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China and Institute of Clinical Basic Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | Clinical value evaluation is the key issue to solve the problems such as high repetition rate, fuzzy clinical positioning, broad indications and unclear clinical values in Chinese herbal formula(Chinese patent medicine). By analyzing the challenges and opportunities of Chinese herbal formula in clinical value evaluation, this paper introduced a strategy of multi-omic network analysis. Through comparative analysis of three stroke treatment formulas, we suggested their different characteristic advantages for variant symptoms or phenotypes of stroke, which may provide reference for rational clinical choice. Such multi-omic network analysis strategy may open a unique angle of view for clinical evaluation and comparison of Chinese herbal formula. |
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| Keywords: | multi-omic Chinese herbal formula clinical value network analysis |
| 本文献已被 CNKI 等数据库收录！ |
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