| 毒性中药蟾酥质量研究现状及关键影响因素分析 |
| |
| 引用本文： | 李宗云,曲婷,王鹏飞,陈两绵,王智民,高慧敏.毒性中药蟾酥质量研究现状及关键影响因素分析[J].中国中药杂志,2017,42(5):863-869. |
| |
| 作者姓名： | 李宗云 曲婷 王鹏飞 陈两绵 王智民 高慧敏 |
| |
| 作者单位： | 哈励逊国际和平医院, 河北 衡水 053000,中国中医科学院 中药研究所, 中药质量控制技术国家工程实验室, 北京 100700,中国中医科学院 中药研究所, 中药质量控制技术国家工程实验室, 北京 100700;天津中医药大学, 天津 300193,中国中医科学院 中药研究所, 中药质量控制技术国家工程实验室, 北京 100700,中国中医科学院 中药研究所, 中药质量控制技术国家工程实验室, 北京 100700,中国中医科学院 中药研究所, 中药质量控制技术国家工程实验室, 北京 100700 |
| |
| 基金项目： | 中央级公益性科研院所基本科研业务费专项（QZPT004） |
| |
| 摘 要： | 蟾酥来源于蟾蜍科动物中华大蟾蜍Bufo bufo gargarizans或黑眶蟾蜍B.melanostictus的干燥分泌物,是我国传统名贵动物药品种,也是国务院颁布的需要特殊管理的28种毒麻中药品种之一。蟾酥富含蟾蜍甾和吲哚生物碱类成分,具有强心、抗肿瘤、镇痛、局麻等多种药理活性。该文从混伪品鉴别、质量控制方法等方面系统归纳了蟾酥质量研究现状,分析了影响质量的关键因素(基原品种、产地、初加工、炮制等)及存在问题,为完善蟾酥及其制剂的质量标准,提升质量控制水平,确保临床安全用药提供参考。
|
| 关 键 词： | 蟾酥 蟾蜍甾 吲哚生物碱 质量控制 |
| 收稿时间： | 2016/12/12 0:00:00 |
Advance on quality control of toad venom and its key influence factors |
| |
| LI Zong-yun,QU Ting,WANG Peng-fei,CHEN Liang-mian,WANG Zhi-min and GAO Hui-min.Advance on quality control of toad venom and its key influence factors[J].China Journal of Chinese Materia Medica,2017,42(5):863-869. |
| |
| Authors: | LI Zong-yun QU Ting WANG Peng-fei CHEN Liang-mian WANG Zhi-min and GAO Hui-min |
| |
| Institution: | Harrison International Peace Hospital, Hengshui 053000, China,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China and National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
| |
| Abstract: | Toad venom (Chansu) is prepared from the dried secretion of Bufo bufo gargarizans or B. melanostictus. It is not only one of the famous and expensive traditional Chinese medicines(TCMs) from animal origin, but also one of 28 kinds of toxic TCMs to be required for special management issued by the State Council of the People''s Republic of China. Chansu contains the rich bufadienolides and indole alkaloids, and displays various bioactivity including cardiotonic, anti-tumor, analgesia, and local anesthesia. Based on the published references in the recent years, the advance on the identification of adulterants and quality evaluation as well as the influence factors on the quality of toad venom was summarized to improve the quality standards and promote the level of quality control of toad venom and its preparations. |
| |
| Keywords: | toad venom bufadienolides indole alkaloids quality control |
| 本文献已被 CNKI 等数据库收录！ |
|
