| 显微技术在牛黄清心丸(局方)质量控制中的应用 |
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| 引用本文： | 聂黎行,张烨,张南平,胡晓茹,康帅,侯建忠,戴忠,马双成. 显微技术在牛黄清心丸(局方)质量控制中的应用[J]. 中国中药杂志, 2016, 41(20): 3741-3745 |
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| 作者姓名： | 聂黎行 张烨 张南平 胡晓茹 康帅 侯建忠 戴忠 马双成 |
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| 作者单位： | 中国食品药品检定研究院, 北京 100050,内蒙古鄂尔多斯市食品药品检验研究中心, 内蒙古 鄂尔多斯 017000,中国食品药品检定研究院, 北京 100050,中国食品药品检定研究院, 北京 100050,中国食品药品检定研究院, 北京 100050,酒泉市药品检验检测中心, 甘肃 酒泉 735000,中国食品药品检定研究院, 北京 100050,中国食品药品检定研究院, 北京 100050 |
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| 基金项目： | 国家自然科学基金项目（81303194）；国家科技重大专项子课题（2014ZX09304307-02） |
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| 摘 要： | 探讨显微技术在牛黄清心丸(局方)质量控制中的应用。对执行标准规定的显微特征进行了总结,并新建了未规定检验项目的山药、羚羊角、肉桂、防风4味药材的显微鉴别方法。首次采用显微技术检查中成药掺伪,建立了牛黄清心丸(局方)中山药混伪品山薯的检查方法。1个厂家的2批次样品未检出羚羊角,2个厂家的3批次抽样检出山薯。所建方法准确、简便、快速、直观、经济,可更加全面地控制牛黄清心丸(局方)的质量。传统的显微技术能够在指标成分缺乏或含量过低的中药的鉴别方面发挥重要作用。
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| 关 键 词： | 牛黄清心丸(局方) 显微 鉴别 检查 掺伪 |
| 收稿时间： | 2016-06-07 |
Application of microscopic spectroscopy in quality control of Niuhuang Qingxin pills |
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| NIE Li-xing,ZHANG Ye,ZHANG Nan-ping,HU Xiao-ru,KANG Shuai,HOU Jian-zhong,DAI Zhong and MA Shuang-cheng. Application of microscopic spectroscopy in quality control of Niuhuang Qingxin pills[J]. China Journal of Chinese Materia Medica, 2016, 41(20): 3741-3745 |
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| Authors: | NIE Li-xing ZHANG Ye ZHANG Nan-ping HU Xiao-ru KANG Shuai HOU Jian-zhong DAI Zhong MA Shuang-cheng |
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| Affiliation: | National Institutes for Food and Drug Control, Beijing 100050, China,Ordos Food and Drug Inspection and Research Center, Orods 017000, China,National Institutes for Food and Drug Control, Beijing 100050, China,National Institutes for Food and Drug Control, Beijing 100050, China,National Institutes for Food and Drug Control, Beijing 100050, China,Jiuquan Center for Drug Inspection and Testing, Jiuquan 735000, China,National Institutes for Food and Drug Control, Beijing 100050, China and National Institutes for Food and Drug Control, Beijing 100050, China |
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| Abstract: | Application of microscopic spectroscopy in quality control of Niuhuang Qingxin pills was discussed. First, microscopic characteristics specified by the statutory standard of Niuhuang Qingxin pills were summarized. Then new identification method was established for Dioscoreae Rhizoma, Saigae Tataricae Cornu, Cinnamomi Cortex and Saposhnikoviae Radix. Finally, microscopic spectroscopy was used for test of Dioscoreae Rhizoma''s adulterant Dioscoreae Fordii Rhizoma.It was the first time for this technology being applied in adulteration test of Chinese patent medicine.The results showed that Saigae Tataricae Cornu was not detected in 2 batches of Niuhuang Qingxin pills from 1 manufacturer while Dioscoreae Fordii Rhizoma was detected in 3 batches of samples from 2 manufacturers. The proposed methods were accurate, simple, rapid, objective and economic, which offered a more comprehensive approach for quality control of Niuhuang Qingxin pills. It was indicated that conventional technology such as microscopic spectroscopy could play an important role in identification of traditional Chinese medicine whose index ingredient was deficient or tiny. |
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| Keywords: | Niuhuang Qingxin pills microscopic spectroscopy identification test adulteration |
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