Effect of semax on homeostasis of gastric mucosa in albino rats |
| |
| Authors: | S. E. Zhuikova E. A. Smirnova Z. V. Bakaeva G. E. Samonina I. P. Ashmarin |
| |
| Affiliation: | (1) Department of Human and Animal Physiology, Biological Faculty of M. V. Lomonosov Moscow State University, Moscow, USSR |
| |
| Abstract: | The ACTH4–7 analogue Semax administered intrapeitoneally in a dose of 50 μg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers and promoted their healing. The antiulcer effects of Semax in the studied dose were comparable with those of tripeptide Pro-Gly-Pro in a dose of 1 mg/kg. Translated fromByulleten “Eksperimental'noi Biologii i Meditsniy, Vol. 130, No. 9, pp. 300–302, September, 2000 |
| |
| Keywords: | proline-containing oligopeptides Semax gastric ulcer |
| 本文献已被 SpringerLink 等数据库收录！ |
|
