Effect of semax on homeostasis of gastric mucosa in albino rats |
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| Authors: | S E Zhuikova E A Smirnova Z V Bakaeva G E Samonina I P Ashmarin |
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| Institution: | (1) Department of Human and Animal Physiology, Biological Faculty of M. V. Lomonosov Moscow State University, Moscow, USSR |
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| Abstract: | The ACTH4–7 analogue Semax administered intrapeitoneally in a dose of 50 μg/kg 1 h before exposure to ulcerogenic factors (ethanol, water
immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax for 5 days after
application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers and promoted their healing. The antiulcer
effects of Semax in the studied dose were comparable with those of tripeptide Pro-Gly-Pro in a dose of 1 mg/kg.
Translated fromByulleten “Eksperimental'noi Biologii i Meditsniy, Vol. 130, No. 9, pp. 300–302, September, 2000 |
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| Keywords: | proline-containing oligopeptides Semax gastric ulcer |
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