| 现代中药表征技术在芪天滴丸稳定性中的应用研究 |
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| 引用本文： | 薛桂蓬,邢建国,李悦,刘宣麟,杨秀,王云飞. 现代中药表征技术在芪天滴丸稳定性中的应用研究[J]. 中成药, 2011, 33(12): 2065-2068 |
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| 作者姓名： | 薛桂蓬 邢建国 李悦 刘宣麟 杨秀 王云飞 |
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| 作者单位： | 新疆维吾尔自治区药物研究所;石河子大学药学院; |
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| 基金项目： | 新疆维吾尔自治区重大科技攻关项目“芪天滴丸的临床前研究”(20053312004) |
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| 摘 要： | 目的对芪天滴丸(黄芪、赤芍、红景天和红花)的稳定性进行研究。方法采用差示扫描量热法(DSC)、X-射线衍射法和扫描电子显微镜(SEM)技术对芪天滴丸的稳定性进行研究。结果 TG曲线说明滴丸在常温下没有导致其质量发生变化的因素;TG/DSC对比分析显示放置两年的芪天滴丸在70°С和430°С左右的吸热峰明显减小;芍药苷对照品、PEG4000、物理混合物和芪天滴丸的比热变化分别为48.470、24.758、9.328、2.058 J/(g.K),相比其他3种物质,滴丸的稳定性最好;滴丸经过0、1、2、3、6个月的加速试验后的X-射线衍射图谱几乎没有变化,无新衍射峰出现,而放置两年的滴丸X-射线衍射图谱有新的衍射峰出现;SEM图揭示滴丸放置两年后存在老化现象。结论这些分析数据提供了芪天滴丸经加速试验后稳定性良好的证据。
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| 关 键 词： | 芪天滴丸 稳定性 差示扫描量热法 X-射线衍射法 扫描电子显微镜 |
Application of DSC,XRD and SEM to stability of Qitian Dripping Pill |
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| XUE Gui-peng,XING Jian-guo,LI Yue,LIU Xuan-ling,YANG Xiu,WANG Yun-fei. Application of DSC,XRD and SEM to stability of Qitian Dripping Pill[J]. Chinese Traditional Patent Medicine, 2011, 33(12): 2065-2068 |
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| Authors: | XUE Gui-peng XING Jian-guo LI Yue LIU Xuan-ling YANG Xiu WANG Yun-fei |
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| Affiliation: | XUE Gui-peng1,XING Jian-guo1,LI Yue2,LIU Xuan-ling1,YANG Xiu2,WANG Yun-fei1(1.Xinjiang Institute of Meteria Medical,Urumqi 830004,China,2.School of Pharmacy,Shihezi University,Shihezi 832000,China) |
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| Abstract: | AIM To study the stability of Qitian Dripping Pill(Astragali Radix,Paeoniae rubra Radix,Rhodiolae roseae Radix et Rhizoma,Carthami Flos).METHODS Differential scanning calorimetry(DSC),X-ray diffraction(XRD) and scanning electron microscopy(SEM) technology were employed to examine the stability of Qitian Dripping Pill which had been stored for two years.RESULTS Thermogravimetry(TG) curve showed that there was no quality change at room temperature.TG/DSC analysis indicated that the endothermic peak of drippin... |
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| Keywords: | Qitian Dropping Pill stability differential scanning calorimetry(DSC) X-ray diffraction(XRD) scanning electron microscopy(SEM) |
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