| 壮骨肾宝对维甲酸致骨质疏松大鼠不同部位骨骼的影响 |
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| 引用本文： | 许碧莲,吴铁,陈文双,崔燎,魏天佑. 壮骨肾宝对维甲酸致骨质疏松大鼠不同部位骨骼的影响[J]. 中成药, 2011, 33(12): 2048-2051 |
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| 作者姓名： | 许碧莲 吴铁 陈文双 崔燎 魏天佑 |
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| 作者单位： | 广东医学院药理教研室;广东医学院广东天然药物研究与开发重点实验室; |
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| 基金项目： | 国家自然科学基金资助项目(30973574); 东莞市科技计划项目(2008108101047) |
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| 摘 要： | 目的探讨壮骨肾宝(淫羊藿、黄芪、白术)对维甲酸致骨质疏松大鼠不同部位骨骼的影响。方法 4月龄的SPF级雌性SD大鼠32只,随机分成正常对照组、维甲酸模型组、壮骨肾宝高剂量组、壮骨肾宝低剂量组,连续给药28 d。大鼠处死后取右侧股骨进行质量、骨密度的测量,取第4腰椎进行生物力学参数测量,取胫骨上段进行骨形态计量学测量。结果与正常对照组相比,维甲酸模型组大鼠股骨质量、骨密度均下降,腰椎生物力学参数弹性载荷、最大载荷、断裂载荷、刚度均下降,胫骨上段静态参数骨组织总面积(T.Ar)、骨小梁面积(Tb.Ar)、骨小梁周长(Tb.Pm)均降低,动态参数标记周长百分数、骨形成率均降低。与维甲酸模型组比较,壮骨肾宝低剂量可使弹性载荷增加,而高剂量使弹性载荷、最大载荷、断裂载荷、刚度均增加,但股骨质量、骨密度和胫骨上段骨形态计量学参数无明显变化。结论壮骨肾宝可预防维甲酸致大鼠腰椎生物力学性能的降低。
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| 关 键 词： | 骨质疏松 维甲酸 壮骨肾宝胶囊 骨密度 骨生物力学 骨形态计量学 |
Effects of Zhuanggu Shenbao on different sites of bones in rats induced by retinoic acid |
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| XU Bi-lian,,WU Tie,CHEN Wen-shuang,CUI Liao,WEI Tian-you. Effects of Zhuanggu Shenbao on different sites of bones in rats induced by retinoic acid[J]. Chinese Traditional Patent Medicine, 2011, 33(12): 2048-2051 |
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| Authors: | XU Bi-lian WU Tie CHEN Wen-shuang CUI Liao WEI Tian-you |
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| Affiliation: | XU Bi-lian1,2,WU Tie1,CHEN Wen-shuang2,CUI Liao1,WEI Tian-you1(1.Dept of Pharmacology,Guangdong Medical College,Zhanjiang 524023,China,2.Guangdong Key Laboratory for Research and Development of Natural Drugs,China) |
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| Abstract: | AIM To investigate the effects of Zhuanggu Shenbao(Epimedii Herba,Astragali Radix,Atractylodis macrocephalae Rhizoma) on different sites of the bones in rats induced by retinoic acid(RA).METHODS Thirty-two four-month-old virgin female Sprague-Dawley rats were randomly divided into control group,RA group,different doses of Zhuanggu Shenbao groups,being treated for 28 days.At the experimental endpoint,weight and bone mineral density(BMD) of femur,biomechanical properties of the forth lumbar vertebrae(LV4),bon... |
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| Keywords: | osteroporosis retinoic acid Zhuanggu Shenbao Capsule BMD biomechanical properties bone histomorphometry |
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