| 白芥子涂方凝胶膏剂的体外释放及透皮特性研究 |
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| 引用本文： | 徐月红,叶卉,官素桃,郭秀彩,刘霞,吴传斌.白芥子涂方凝胶膏剂的体外释放及透皮特性研究[J].中成药,2011,33(12):2068-2072. |
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| 作者姓名： | 徐月红 叶卉 官素桃 郭秀彩 刘霞 吴传斌 |
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| 作者单位： | 中山大学药学院; |
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| 基金项目： | 国家自然科学基金资助项目(81073066); 广东省中医药管理局项目[2008]29号 |
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| 摘 要： | 目的研究白芥子涂方(白芥子、延胡索、甘遂、细辛等)凝胶膏剂的体外释放和透皮特性,为开发白芥子涂方贴敷预防和治疗哮喘的药物新型给药系统提供实验支持。方法分别以透析膜和大鼠皮肤为屏障,以扩散池法进行体外释放和透皮实验,以方中君药白芥子的有效成分芥子碱硫氰酸盐为指标,利用反相高效液相色谱分析,测定白芥子涂方凝胶膏剂释放介质和透皮接收液中的药物浓度,分别以累积释放量和透皮量对时间做图,计算释放和透皮速率。结果芥子碱硫氰酸盐自凝胶膏剂中体外释放的方程为QR=45.65t+3.193,r2=0.994 6,释放速率为45.65μg/(cm2.h);其透皮特性方程为QT=0.502 1t+0.178 0,r2=0.997 1;透皮速率0.502 1μg/(cm2.h)。结论芥子碱硫氰酸盐的释放速率远大于透皮速率,释放速率可保证其稳定透皮的动力,其透皮过程不受其释放的限制,限速步骤主要是由于皮肤的屏障作用导致,寻找合适的透皮促进剂对白芥子涂方凝胶膏剂发挥疗效具有重要意义。
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| 关 键 词： | 白芥子涂方 凝胶膏剂 体外释放 透皮特性 |
Study on release and permeation behavior of Baijiezi Tufang hydrogel patch in vitro |
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| XU Yue-hong,YE Hui,GUAN Su-tao,GUO Xiu-cai,LIU Xia,WU Chuan-bin.Study on release and permeation behavior of Baijiezi Tufang hydrogel patch in vitro[J].Chinese Traditional Patent Medicine,2011,33(12):2068-2072. |
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| Authors: | XU Yue-hong YE Hui GUAN Su-tao GUO Xiu-cai LIU Xia WU Chuan-bin |
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| Institution: | XU Yue-hong,YE Hui,GUAN Su-tao,GUO Xiu-cai,LIU Xia,WU Chuan-bin(School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China) |
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| Abstract: | AIM To study the release and permeation behavior of Baijiezi Tufang hydrogel patch(Semen Brassicae,Corydalis Rhizoma,Kansui Radix,Asari Herba,etc.) in vitro to be used in the treatment of asthma prevention and care.METHODS Dialysis membrane and rat skin were used as the barriers respectively.The release and permeation experiment were carried out with Franz diffusion cell in vitro.Sinapine thiocyanate was used as a marker,and detected by reverse phase high performance liquid chromatography(RP-HPLC).The accum... |
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| Keywords: | Baijizi Tufang hydrogel patch release in vitro permeation behavior |
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