| 顶空气相色谱法测定贯叶金丝桃提取物中大孔树脂有机溶剂残留物 |
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| 引用本文： | 樊敏伟,秦晶,何红伟,韩丽妹,王建新. 顶空气相色谱法测定贯叶金丝桃提取物中大孔树脂有机溶剂残留物[J]. 中成药, 2011, 33(10): 1748-1750 |
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| 作者姓名： | 樊敏伟 秦晶 何红伟 韩丽妹 王建新 |
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| 作者单位： | 1. 复旦大学药学院药剂学教研室教育部和全军智能化递药重点实验室,上海201203;国家中药制药工程技术研究中心,上海201203
2. 复旦大学药学院药剂学教研室教育部和全军智能化递药重点实验室,上海,201203 |
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| 摘 要： | 目的 建立贯叶金丝桃大孔树脂提取物中正己烷、苯、甲苯、对二甲苯、邻二甲苯、苯乙烯、1,2-二乙基苯等7种有机溶剂的残留量的测定方法.方法 将提取物溶解于0.6％的十二烷基硫酸钠水溶液中,采用HP-INNOWAX毛细管柱和FID检测器,以高纯氮气为载气;应用顶空气相色谱法测定贯叶金丝桃大孔树脂提取物中7种有机溶剂的残留量.结果 该方法可将7种有机溶剂完全分离,且线性关系良好;精密度和重复性RSD均小于7％,平均同收率在82.6％ ～104.0％之间.结论 此法简便、快速、准确,可用于大孔树脂制备的贯叶金丝桃提取物中有机残留溶剂的质量控制.
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| 关 键 词： | 贯叶金丝桃提取物 大孔吸附树脂 顶空气相色谱法 有机溶剂残留量 |
Determination of organic residues from macroporous adsorption resin in St.John's Wort extract by capillary gas chromatography with headspace sampling |
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| FAN Min-wei , QIN Jing , HE Hong-wei , HAN Li-mei , WANG Jian-xin. Determination of organic residues from macroporous adsorption resin in St.John's Wort extract by capillary gas chromatography with headspace sampling[J]. Chinese Traditional Patent Medicine, 2011, 33(10): 1748-1750 |
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| Authors: | FAN Min-wei QIN Jing HE Hong-wei HAN Li-mei WANG Jian-xin |
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| Affiliation: | FAN Min-wei1,2,QIN Jing1,HE Hong-wei1,HAN Li-mei1,WANG Jian-xin1(1.Key Laboratory of Smart Drug Delivery,Ministry of Edmcation & PLA,Department of Pharmaceutics,School of Pharmacy,Fudan University,Shanghai 201203,China,2.National Center for Traditional Chinese Medicine Preparations,China) |
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| Abstract: | AIM To develop a method for determining organic residues(including hexane,benzene,toluene,paraxylene,o-xylene,styrene and 1,2-diethyl benzene) from macroporous adsorption resin in St.John's Wort extract.METHODS The extract was dissolved in 0.6% SDS solution.The content of organic residues was analyzed by capillary gas chromatography with headspace sampling.RESULTS The linear regression coefficients between peak areas and concentration of seven residues were good(r>0.997 0).The recoveries were in the range o... |
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| Keywords: | St John's Wort extract macroporous adsorption resin organic residues capillary gas chromatography with headspace sampling |
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