| 基于Box-Behnken实验优化龙血竭固体脂质纳米粒的制备 |
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| 引用本文： | 郝吉福,王建筑,郭丰广,孔志峰,李菲,彭新生.基于Box-Behnken实验优化龙血竭固体脂质纳米粒的制备[J].中成药,2011,33(10):1713-1718. |
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| 作者姓名： | 郝吉福 王建筑 郭丰广 孔志峰 李菲 彭新生 |
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| 作者单位： | 1. 山东泰山医学院药学院,山东泰安,271016
2. 广东医学院药学院,广东东莞,523808 |
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| 基金项目： | 广东省科技计划(2011B03710058); 国家青年科学基金(81102820) |
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| 摘 要： | 目的 基于Box-Behnken实验设计探讨影响龙血竭固体脂质纳米粒的处方因素以优化最佳处方.方法 以龙血竭为模型药物,采用乳化蒸发-低温固化法制备固体脂质纳米粒.利用三因素三水平Box-Behnken实验设计,考察单硬脂酸甘油酯的用量(X1),泊洛沙姆188的用量(X2)以及药物的比例(X3)对固体脂质纳米粒包封率(Y1)、浊度(y2)和载药量(Y3)的影响,通过建立相应的二项式数学模型优化处方.结果 最优处方为固体脂质纳米粒中脂质单硬脂酸甘油酯用量为5％,5.39％的poloxmer 188作为乳化剂,含药物量为15％.结论 采用Box-Behnken实验没计可用于龙血竭固体脂质纳米粒的处方优化筛选.
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| 关 键 词： | 龙血竭 Box-Behnken设计 固体脂质纳米粒 效应面法 |
Preparation and optimization of Resina Draconis loading solid lipid nanoparticle by using Box-Behnken design |
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| HAO Ji-fu
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WANG Jian-zhu
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GUO Feng-guang
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KONG Zhi-feng
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LI Fei
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PENG Xin-sheng.Preparation and optimization of Resina Draconis loading solid lipid nanoparticle by using Box-Behnken design[J].Chinese Traditional Patent Medicine,2011,33(10):1713-1718. |
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| Authors: | HAO Ji-fu WANG Jian-zhu GUO Feng-guang KONG Zhi-feng LI Fei PENG Xin-sheng |
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| Institution: | HAO Ji-fu1,WANG Jian-zhu1,GUO Feng-guang1,KONG Zhi-feng1,LI Fei1,PENG Xin-sheng2*(1.Pharmacy Department of Taishan Medical College,Taian 271006,China,2.School of Pharmaceutical Sciences,Guangdong Medical College,Dongguan 523808,China) |
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| Abstract: | AIM To apply Box-Behnken design to investigate main and interaction effects of formulation parameters in optimizing solid lipid nanoparticle of Resina Draconis formulation.METHODS Solid lipid nanoparticles were prepared by the emulsion-evaporation and low temperature-solidification technique using Resina Draconis as model drug.A three-factor,three-level Box-Behnken experimental design was employed to construct a second order polynomial equation for the optimized procedure,with the amount of glycerol monoste... |
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| Keywords: | Resina Draconis Box-Behnken design solid lipid nanoparticles response surface methodology |
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