| 淫羊藿苷隐形固体脂质纳米粒的制备及体外释放度研究 |
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| 引用本文： | 张晓娟,刘科攀,王丽峰,王阳.淫羊藿苷隐形固体脂质纳米粒的制备及体外释放度研究[J].中成药,2011,33(11):1905-1907. |
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| 作者姓名： | 张晓娟 刘科攀 王丽峰 王阳 |
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| 作者单位： | 天津中医药大学中药学院;天津中医药大学实验教学部; |
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| 基金项目： | 天津市高等学校科技发展基金计划项目(20060302); 天津市自然科学基金资助项目(09TCYBTC13500) |
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| 摘 要： | 目的 对淫羊藿苷隐形固体脂质纳米粒的制备工艺进行优化并考察了体外释放规律.方法 按均匀设计U6(64)优化处方,采用高温熔融-低温固化法制备淫羊藿苷隐形固体脂质纳米粒,以包封率、载药量、粒径及Zeta电位的综合评分为考察指标,优选处方配比;用HPLC测定了淫羊藿苷溶液及隐形固体脂质纳米粒的体外释放百分率.结果 制得的淫...
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| 关 键 词： | 均匀设计 淫羊藿苷 隐形同体脂质纳米粒 体外释放度 |
Preparation and in vitro release of icariin stealth solid liposomes nanoparticles |
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| ZHANG Xiao-juan,LIU Ke-pan,WANG Li-feng,WANG Yang.Preparation and in vitro release of icariin stealth solid liposomes nanoparticles[J].Chinese Traditional Patent Medicine,2011,33(11):1905-1907. |
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| Authors: | ZHANG Xiao-juan LIU Ke-pan WANG Li-feng WANG Yang |
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| Institution: | ZHANG Xiao-juan1,LIU Ke-pan1,WANG Li-feng2,WANG Yang1(1.College of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China,2.Experimental Teaching Administration Department,China) |
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| Abstract: | AIM To optimize the formulation for the preparation of the icariin stealth solid lipid nanoparticles(Ica-SSLN) and to investigate their release in vitro.METHODS The optimal preparation was selected by U6(64) uniform design.Ica-SSLN was prepared by high temperature melting-cool solidification method.The comprehensive score of the entrapment efficiency,ratio of loading drug,diameter and the Zeta potential were used as index.And the release rate of icariin in vitro was determined by HPLC.RESULTS The entrapment... |
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| Keywords: | uniform design icariin stealth solid lipid nanoparticles release rate in vitro |
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