| IGF-1、COX-2在宫颈病变组织中的表达及临床意义 |
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| 引用本文： | 刘金峰,李盛,李伟. IGF-1、COX-2在宫颈病变组织中的表达及临床意义[J]. 现代医学, 2013, 0(10): 732-735 |
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| 作者姓名： | 刘金峰 李盛 李伟 |
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| 作者单位： | [1]蔚县蔚州中心卫生院妇产科,河北蔚县075700 [2]开滦集团蔚州矿业公司职工医院普外科,河北蔚县075700 [3]中国人民解放军251医院病理科,河北张家口075000 |
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| 摘 要： | 目的：探讨胰岛素样生长因子1（IGF-1）、环氧化酶-2（COX-2）在宫颈病变组织中的表达及临床意义。方法：应用免疫组织化学（EnVision“）法分别检测IGF-1、COX-2在30例正常组织、30例宫颈鳞状上皮内瘤变组织和70例恶性病变组织中的表达情况。结果：在正常组织、宫颈鳞状上皮内瘤变组织及宫颈鳞状细胞癌组织中，IGF-1的表达阳性率分别为0、3．33％和61．43％，差异有统计学意义（疋。=51．68，P〈0．01）；在正常组织、宫颈鳞状上皮内瘤变组织及宫颈鳞状细胞癌组织中，COX-2的表达阳性率分别为0、6．67％和51．43％，差异有统计学意义（矿=36．45，P〈0．01）。IGF-1的表达与肿瘤大小、淋巴结转移、远处脏器转移、FIGO分期有关，差异均有统计学意义（P〈0．05），但与年龄、组织学类型无关，差异无统计学意义（P〉0．05）；COX-2的表达与淋巴结转移、远处脏器转移、FIGO分期有关，差异均有统计学意义（P〈0．05），但与肿瘤大小、年龄、组织学类型无关，差异无统计学意义（P〉0．05）。IGF-1表达与COX-2表达呈显著正相关（r=0．64，P〈0．01）。结论：IGF-1、COX-2在宫颈鳞状细胞癌组织中呈现过表达，检测两者的表达可在-定程度上反映患者的预后。
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| 关 键 词： | 宫颈鳞状细胞癌 胰岛素样生长因子1 环氧化酶-2 免疫组织化学 |
Expression of IGF-1 and COX-2 in cervial diseases and their clinical significance |
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| LIU Jin-feng,LI Sheng,LI Wei. Expression of IGF-1 and COX-2 in cervial diseases and their clinical significance[J]. Modern Medical JOurnal, 2013, 0(10): 732-735 |
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| Authors: | LIU Jin-feng LI Sheng LI Wei |
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| Affiliation: | 1. Department of @naecology and Obstetrics, the Central Hospital of Yu State, Yuxian 075700 China ; 2. Department of Genernal Surgery, the Staff- Worker Hospital of the Mining Industry Company of Kailuan Clique, Yuxian 075700, China ; 3. Department of Pathology, the 251 th Hospital of PIA , Zhangjiakou 075000, China) |
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| Abstract: | Objective： To investigate the expression of IGF-1 and COX-2 in cervial diseases and their clinical significance. Methods： The expression of IGF-1 and COX-2 was detected bylmmunohlstochemlsty（ Enhvlon^TM ） in 30 normal control, 30 cervical squamous intraepithelial neoplasia and 70 malignant lesion. Results： The expression rate of IGF-1 protein in normal controls cervical squamous intraepithelial neoplasia and cervical squamous-cell carcinoma was respectively 0%, 3.33% and 61.43% with statistical significance among them （X2 = 51.68, P 〈 O. 01）. The expression rate of COX-2 protein in normal control, cervical squamous intraepithelial neoplasia and cervical squamous-cell carcinoma was respectively 0% , 6.67% and 51.43% , the difference being statistically significant among them（x2 = 36.45,P 〈 O. O1 ）. The expression of IGF- 1 was related to tumor size, lymph node metastasis, distant organ metastasis and FIGO staging（P 〈0.05 ）, but not to age and histological type（ P 〉0.05 ）. The expression of COX- 2 was related to lymph node metastasis, distant organ metastasis and FIGO staging （ P 〈 0.05） ,but not to tumor size, age and histological type （P 〉 0.05 ）. There was obviously positive correlation between IGF and COX-2 （r = 0. 64, P 〈 0.01 ）. Conclusion： IGF and COX-2 are overly expressed in cervical squamous-cell carcinoma tissue, a combination of the two may reflect patient＇s prognosis. |
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| Keywords: | cervical squamous- cell carcinoma IGF- 1 COX-2 immunohistochemisty |
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