| Correlated Flow Cytometric Analysis of H－ras p21 and DNA Ploidy in Acute Myelogenous Leukemia |
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| 引用本文： | 林凤茹,刘素云,任金海,卫俊萍,徐世荣,刘润生,姚尔国.Correlated Flow Cytometric Analysis of H－ras p21 and DNA Ploidy in Acute Myelogenous Leukemia[J].华中科技大学学报(医学英德文版),1996,16(2):75-77. |
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| 作者姓名： | 林凤茹 刘素云 任金海 卫俊萍 徐世荣 刘润生 姚尔国 |
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| 作者单位： | Hematology Research Laboratory，Second Affiliated Hospital，Hebei Medical University，Shijiazhung 050000 |
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| 摘 要： | ＣｏｒｒｅｌａｔｅｄＦｌｏｗＣｙｔｏｍｅｔｒｉｃＡｎａｌｙｓｉｓｏｆＨ－ｒａｓｐ２１ａｎｄＤＮＡＰｌｏｉｄｙｉｎＡｃｕｔｅＭｙｅｌｏｇｅｎｏｕｓＬｅｕｋｅｍｉａＬＩＮＦｅｎｇｒｕ（林凤茹），ＬＩＵＳｕｙｕｎ（刘素云），ＲＥＮＪｉｎｈａｉ（任金海），Ｗ...
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| 收稿时间： | 5 September 1995 |
Correlated flow cytometric analysis of H-ras p21 and DNA ploidy in acute myelogenous leukemia |
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| Lin Fengru,Liu Suyun,Ren Jinhai,Wei Junping,Xu Shirong,Liu Runsheng,Yao Ergu.Correlated flow cytometric analysis of H-ras p21 and DNA ploidy in acute myelogenous leukemia[J].Journal of Zuazhong University of Science and Technology: Medical Edition,1996,16(2):75-77. |
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| Authors: | Lin Fengru Liu Suyun Ren Jinhai Wei Junping Xu Shirong Liu Runsheng Yao Ergu |
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| Institution: | (1) Hematology Research Laboratory, Second Affiliated Hospital, Hebei Medical University, 050000 Shijiazhung |
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| Abstract: | The flow cytometric immunoassay was used to study the correlation between the H-ras oncogene product p21 and the DNA ploidy in 30 de novo cases of acute myelogenous leukemia (AML). The results showed that 17 cases were negative for p21 expression and 13 positive for p21. The patients with positive p21 had higher percentage of bone marrow and peripheral blasts and lower peripheral leukocyte count. The expression of p21 had no influence on the therapeutic effect. Before treatment,DNA diploidy occurred in 18 cases including 13 p21 negative ones,and DNA aneuploidy was revealed in 12 cases including 8 p21 positive ones. Patients with positive p21 or having aneuploidy in complete remission were at risk for early relapse. Our results suggest that p21 may be involved in the process of leukemogenesis and progression in AML. |
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| Keywords: | ras oncogene product p21 DNA ploidy flow cytometry acute myelogenous Leukemia |
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