血压变异性与心脑血管疾病及预后的关系研究

血压变异性（blood pressure variability，BPV）因其与靶器官损害有一定关系，具有临床意义， 关注度日趋增高，国内外关于血压变异性与高血压靶器官损害的相关研究也屡见报道，越来越多的 证据表明，血压变异性越大，高血压靶器官损害越严重。血压变异性的高低对预测高血压左心室肥 厚（left ventricular hypertrophy，LVH）及靶器官损害（target organ damage，TOD）和不良心血管事件具 有重要价值。本文从血压变异性的定量分析、调控机制、对心脑血管疾病的影响及其引起靶器官损 害的机制、临床意义5个方面对近年来血压变异性的相关研究进展进行综述，以期通过降低血压变 异性来防止高血压靶器官的损害及临床伴随疾病的发生。

Blood Pressure Variability Correlates with Target Organ Damage and its Prognosis

Blood pressure variability（BPV） becomes more and more important because of its relationship between target organ damage and clinical signifi cance. The related researches reported in the papers increased. Related researches on blood pressure variability and hypertensive target organ damage are also often found in reports. More and more evidence suggests that the greater of the blood pressure variability, the more severe hypertensive target organ damage. Blood pressure variability had a great value in predicting the level of left ventricular hypertrophy（LVH） and target organ damage and clinical cardiovascular events. This review summarized a lot of studies in recent years about blood pressure variability, including quantitative analysis, the regulation mechanism, target organ damage and the mechanism of target organ damage, and clinical signifi cance.